Lang I M, Mackman N, Kriett J M, Moser K M, Schleef R R
Division of Pulmonary and Critical Care Medicine, University of California at San Diego 92037, USA.
Hum Pathol. 1996 Apr;27(4):423-7. doi: 10.1016/s0046-8177(96)90118-5.
Activation of endothelial cells occurs in response to numerous physiological stimuli and results in the concerted expression of endothelial cell proteins that change the nonthrombogenic intimal surface of a vessel into a thrombogenic surface, with the subsequent development of local thrombosis. For example, both type 1 plasminogen activator inhibitor and tissue factor expression are mediated by endothelial cell stimulation in vitro; however, in contrast to type 1 plasminogen activator inhibitor, it has been difficult to detect tissue factor associated with endothelial cells in vivo. This case study describes the presence of both type 1 plasminogen activator inhibitor and tissue factor antigen associated with pulmonary arterial endothelial cells of a patient exhibiting a mycobacterial infection. The disease was associated with chronic hemoptysis and characterized by extensive tissue destruction and local thrombosis within the pulmonary artery. The data show that conditions occur in vivo in which local thrombosis is associated with increased levels of type 1 plasminogen activator inhibitor and tissue factor.
内皮细胞的激活是对多种生理刺激的反应，导致内皮细胞蛋白的协同表达，从而将血管的非血栓形成内膜表面转变为血栓形成表面，随后发生局部血栓形成。例如，1型纤溶酶原激活物抑制剂和组织因子的表达在体外均由内皮细胞刺激介导；然而，与1型纤溶酶原激活物抑制剂不同，在体内很难检测到与内皮细胞相关的组织因子。本病例研究描述了一名患有分枝杆菌感染患者的肺动脉内皮细胞中同时存在1型纤溶酶原激活物抑制剂和组织因子抗原。该疾病与慢性咯血有关，其特征是广泛的组织破坏和肺动脉内的局部血栓形成。数据表明，体内存在局部血栓形成与1型纤溶酶原激活物抑制剂和组织因子水平升高相关的情况。
