Kang J Y, Teng C H, Chen F C
Department of Medicine, National University of Singapore.
Gut. 1996 Jun;38(6):832-6. doi: 10.1136/gut.38.6.832.
Capsaicin protects the gastric mucosa against experimental injury while capsaicin desensitisation reduces the rate of gastric ulcer healing. The effect of exogenous capsaicin on gastric ulcer healing has not to date been reported.
AIM/METHOD: To investigate the effect of capsaicin, cimetidine, and in combination, given intragastrically in the healing of acetic acid induced chronic gastric ulcer in the rat. Treatment started immediately after ulcer induction.
At the end of one week, capsaicin, cimetidine, and in combination increased ulcer healing but the effect of combined treatment was less than that of capsaicin alone. In an in vivo gastric chamber preparation, capsaicin increased, while cimetidine decreased, gastric mucosal blood flow measured by laser Doppler flowmetry. A dose response effect in reduction of gastric mucosal blood flow could be demonstrated for cimetidine. The gastric hyperaemic effect of capsaicin was blunted by prior administration of cimetidine. In contrast, capsaicin had no effect on gastric acid secretion and its addition to cimetidine did not affect the acid suppressant effect of the latter.
Capsaicin promotes the healing of acetic acid induced gastric ulcer, probably by its gastric hyperaemic effect. Although cimetidine also promotes ulcer healing due to its inhibitory effect on acid secretion it may have an antagonistic effect on the gastric ulcer healing effect of capsaicin by virtue of inhibition of gastric hyperaemia.
辣椒素可保护胃黏膜免受实验性损伤，而辣椒素脱敏则会降低胃溃疡的愈合速度。迄今为止，外源性辣椒素对胃溃疡愈合的影响尚未见报道。
目的/方法：研究辣椒素、西咪替丁及其联合应用对大鼠乙酸诱导的慢性胃溃疡愈合的影响。在溃疡诱导后立即开始治疗，通过胃内给药。
在一周结束时，辣椒素、西咪替丁及其联合应用均能促进溃疡愈合，但联合治疗的效果不如单独使用辣椒素。在体内胃腔制备实验中，辣椒素可增加胃黏膜血流量，而西咪替丁则会降低胃黏膜血流量，通过激光多普勒血流仪测量。西咪替丁对胃黏膜血流量的减少具有剂量反应效应。预先给予西咪替丁可减弱辣椒素的胃充血效应。相反，辣椒素对胃酸分泌无影响，将其与西咪替丁联合使用也不会影响后者的抑酸效果。
辣椒素可能通过其胃充血效应促进乙酸诱导的胃溃疡愈合。虽然西咪替丁因其对胃酸分泌的抑制作用也能促进溃疡愈合，但它可能通过抑制胃充血对辣椒素的胃溃疡愈合作用产生拮抗作用。
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