Dickinson H O, Parker L, Binks K, Wakeford R, Smith J
University of Newcastle, Department of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne.
J Epidemiol Community Health. 1996 Dec;50(6):645-52. doi: 10.1136/jech.50.6.645.
To investigate whether the occupational exposure to external ionising radiation of men employed at the Sellafield nuclear installation, West Cumbria, affects the sex of the children they subsequently father.
A retrospective cohort study using logistic regression to analyse the sex ratio, in particular in relation to paternal preconceptional irradiation.
The 260,060 singleton births between 1950 and 1989 to mothers resident in Cumbria, north west England.
The sex ratio among children of men employed at any time at Sellafield was 1.094 (95% CI: 1.060, 1.128), significantly higher than that among other Cumbrian children, 1.055 (95% CI: 1.046, 1.063). There was an increased sex ratio of 1.396 (95% CI: 1.127, 1.729) in the 345 children whose fathers were estimated from annual dose summaries to have received more than 10 mSv of external radiation in the 90 days preceding conception, but no significant linear trend between sex ratio and 90 day paternal preconceptional dose was found. There was no significant association between sex ratio and the external dose accumulated before the 90 day period preceding conception.
Men employed at Sellafield fathered a greater proportion of boys than would be expected for a Cumbrian population, which may be partly explained by their younger age distribution. A greater effect was observed in the fathers with recorded doses exceeding 10 mSv in the 90 days before conception. While this may reflect a true statistical association, it is also possible that it may be a chance finding due to imprecision in the dose estimates and consequent misclassification.
调查西坎布里亚郡塞拉菲尔德核设施男性工作人员的职业性外照射电离辐射暴露是否会影响其后续所育子女的性别。
一项回顾性队列研究，采用逻辑回归分析性别比，特别是与父亲受孕前辐射的关系。
1950年至1989年间居住在英格兰西北部坎布里亚郡的母亲所生育的260,060例单胎婴儿。
曾在塞拉菲尔德工作过的男性所育子女的性别比为1.094（95%可信区间：1.060, 1.128），显著高于其他坎布里亚郡儿童的性别比1.055（95%可信区间：1.046, 1.063）。根据年度剂量总结估计，在受孕前90天内接受超过10 mSv外照射的345名儿童的父亲，其子女的性别比为1.396（95%可信区间：1.127, 1.729），但未发现性别比与受孕前90天父亲剂量之间存在显著的线性趋势。性别比与受孕前90天之前累积的外照射剂量之间无显著关联。
塞拉菲尔德的男性工作人员所育男孩的比例高于坎布里亚郡人群的预期比例，这可能部分归因于他们更年轻的年龄分布。在受孕前90天记录剂量超过10 mSv的父亲中观察到了更大的影响。虽然这可能反映了一种真实的统计学关联，但也有可能是由于剂量估计不准确及随之而来的错误分类导致的偶然发现。
