Nagata K, Kondoh Y, Satoh Y, Watahiki Y, Yokoyama E, Yuya H, Hirata Y, Shishido F, Hatazawa J, Kanno I
Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan.
Clin Neuropharmacol. 1993 Dec;16(6):501-10. doi: 10.1097/00002826-199312000-00003.
To evaluate the effect of the novel intracellular calcium antagonist fasudil hydrochloride, cerebral blood flow (CBF) was measured quantitatively with positron emission tomography following the intravenous administration of fasudil in five patients with chronic cerebral infarction. The hemispheric mean CBF increased significantly on both hemispheres 30, 60, and 90 min after the administration of fasudil when the CBF values were corrected according to PaCO2 level, although there was no significant change in raw CBF data. A significant increase of CBF was seen in the cerebellar hemisphere and thalamus at 30 min and in the occipital cortex at 90 min. There was no significant fall in the systemic blood pressure after the administration of fasudil.
为评估新型细胞内钙拮抗剂盐酸法舒地尔的作用，对5例慢性脑梗死患者静脉注射法舒地尔，随后用正电子发射断层扫描定量测量脑血流量（CBF）。当根据动脉血二氧化碳分压（PaCO2）水平校正CBF值时，注射法舒地尔30、60和90分钟后，双侧半球的半球平均CBF显著增加，尽管原始CBF数据无显著变化。在30分钟时，小脑半球和丘脑的CBF显著增加，在90分钟时，枕叶皮质的CBF显著增加。注射法舒地尔后，全身血压无显著下降。
