Tomoda H, Baba H, Akazawa K
Department of Surgery, National Nakatsu Hospital, Nakatsu, Oita 871-0011, Japan.
Oncol Rep. 1999 Mar-Apr;6(2):321-4. doi: 10.3892/or.6.2.321.
We compared the survival between 46 patients with hereditary nonpolyposis colorectal cancer (HNPCC) and 1185 cases with sporadic colorectal cancer, who underwent a resection for the disease between 1972 and 1995. In a univariate analysis, the survival correlated well with stage, curability, size and the presence of HNPCC. Patients with HNPCC had a longer survival than those with sporadic colorectal cancer (P=0.0277). A multivariate analysis suggested that stage, curability, age, and HNPCC were the effective combination of factors predictive of survival. The above findings are thus expected to have a major influence on the evaluation of clinical trials in patients with colorectal cancer.
