Molecular prognostic markers in intermediate-thickness cutaneous malignant melanoma.
作者信息
Hieken T J, Ronan S G, Farolan M, Shilkaitis A L, Das Gupta T K
机构信息
Department of Surgical Oncology, University of Illinois at Chicago, USA.
出版信息
Cancer. 1999 Jan 15;85(2):375-82. doi: 10.1002/(sici)1097-0142(19990115)85:2<375::aid-cncr15>3.0.co;2-1.
BACKGROUND
The limitations of morphologic criteria alone in determining the prognosis for a patient with a particular intermediate-thickness primary melanoma have prompted efforts to identify other markers.
METHODS
In this study, the authors analyzed expression of p53, beta1 integrin, and beta3 integrin in primary tumors from 111 patients with intermediate-thickness malignant melanoma.
RESULTS
Eighty-nine (80%) had detectable p53 protein, 58 (52%) expressed beta1 integrin, and 71 (64%) expressed beta3 integrin. Patients with beta3 positive melanomas were more likely to die of their disease (32 of 71 patients, 45%) than those with beta3 negative tumors (3 of 40 patients, 8%) (P < 0.0001). The number of involved lymph nodes, Clark's level, beta1 integrin expression, thickness, and mitotic rate also had prognostic significance. beta3 integrin was associated with subsequent lung metastases and beta1 integrin with lymph node involvement.
CONCLUSIONS
Integrin expression, along with histopathologic criteria, is a prognostic marker for intermediate-thickness malignant melanoma and may indicate the site of subsequent metastasis. These observations may have clinical utility and suggest areas for future investigation.
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