Schönheit B, Schulz E
J Hirnforsch. 1976;17(3):171-87.
At three months old male rats the spine-distribution of the main dendrite and of the apical and basal dendrites of 36 lamina V-pyramidal cells of the regio cingularis (anterior cingulate cortex) was analyzed (from every subregion -- neocortex, mesoneocortex, mesoarchicortex -- 12 neurons). 1. The limbic pyramidal neurons show the same spine-distribution at their main dendrite as neocortical neurons of other brain regions and other mammal-species do: after an initial segment with poor spines only there follows an rapid increase of the spine-values with an amount at a range of 150 mum from the perikaryon, thereafter spine-values decrease continuously and slowly up the branching into the terminal bundle. 2. Basal and apical lateral dendrites however show another spine-distribution: basally there is an increase of the spine-values from the 1st up to the 3rd order, followed by a decrease at subsequent orders. Apically spine-density decreases from the 1st up to the 4th order. 3. The spine-distribution at the parts of the dendritic tree is discussed as a general biological sign of pyramidal cells. 4. The total number of spines of lamina V-pyramidal cells in the regio cingularis (anterior cingulate cortex) is less than those in the sensomotoric cortex and in the hippocampus, which corresponds with the lower differentiation of the limbic cortex. 5. By means of a variance-analysis the pyramidal spine-values of the three subregions were compared: concerning the total number of spines of a pyramidal neuron there are significant differences between the three subregions; the values are in the ratio of 3 to 2 to 1 (Regio praecentralis agranularis, 2461; mesoneocortex, 1664; mesoarchicortex, 800). The significantly least spine-density of all parts of the dendritic tree you can find in lamina V-pyramidal cells of the mesoarchicortex. 6. The equality of the basal and apical spine-values in the mesoneocortex is due to less specialization of these neurons. 7. The spine-values for a single dendritic field (EDF) show the differences between the limbic subregions clearly: there are significant differences between the three subregions concerning not only the number of spines but also the spine-densities apically and basally.
对3个月大的雄性大鼠扣带回区域（前扣带回皮质）36个V层锥体细胞的主树突以及顶树突和基树突的棘分布进行了分析（从每个亚区域——新皮质、中脑新皮质、中脑旧皮质——选取12个神经元）。1. 边缘锥体细胞主树突的棘分布与其他脑区及其他哺乳动物物种的新皮质神经元相同：在起始段棘较少之后，从胞体起150μm范围内棘值迅速增加，此后棘值持续缓慢下降直至分支进入终末束。2. 然而，基树突和顶侧树突显示出另一种棘分布：基部从一级到三级棘值增加，随后各级减少。顶部棘密度从一级到四级降低。3. 树突树各部分的棘分布被作为锥体细胞的一般生物学标志进行讨论。4. 扣带回区域（前扣带回皮质）V层锥体细胞的棘总数少于感觉运动皮质和海马体中的棘总数，这与边缘皮质较低的分化程度相对应。5. 通过方差分析比较了三个亚区域的锥体棘值：关于一个锥体细胞的棘总数，三个亚区域之间存在显著差异；数值比例为3:2:1（无颗粒中央前区，2461；中脑新皮质，1664；中脑旧皮质，800）。在中脑旧皮质的V层锥体细胞中，可发现树突树所有部分的棘密度显著最低。6. 中脑新皮质中基部和顶部棘值相等是由于这些神经元的特化程度较低。7. 单个树突场（EDF）的棘值清楚地显示了边缘亚区域之间的差异：三个亚区域之间不仅在棘的数量上，而且在顶部和基部的棘密度上都存在显著差异。
