浆细胞异常增殖症中的可溶性CD16

Soluble CD16 in plasma cell dyscrasias.

作者信息

Mathiot C, Galon J, Tartour E, Teillaud J L, Facon T, Bataille R, Fridman W H, Sautès C

机构信息

Hématologie biologique, INSERM U255, Institut Curie, Paris, France.

出版信息

Leuk Lymphoma. 1999 Feb;32(5-6):467-74. doi: 10.3109/10428199909058404.

DOI:10.3109/10428199909058404

PMID:10048419

Abstract

Soluble forms of Fc gammaR type III (sFc gammaRIII or sCD16) are present in many biological fluids. Their main ligand is IgG in the form of complexes. In plasma, sCD16 essentially derive from cleavage of membrane CD16 (or Fc gammaRIII) present on neutrophils and, to a lesser extent, on NK cells. Determination of sCD16 serum level during monoclonal gammopathies has demonstrated markedly reduced levels in multiple myeloma and in monoclonal gammopathy of undetermined significance (MGUS) rapidly evolving to multiple myeloma, compared to stable MGUS or controls, indicating a prognostic value for this biological parameter. The biology and functions of sCD16 are described, together with the biological significance of modifications of the sCD16 serum level in monoclonal gammopathies.

摘要

可溶性III型Fcγ受体（sFcγRIII或sCD16）存在于多种生物体液中。其主要配体是复合物形式的IgG。在血浆中，sCD16主要来源于中性粒细胞表面膜CD16（或FcγRIII）的裂解，在较小程度上也来源于自然杀伤细胞表面膜CD16的裂解。在单克隆丙种球蛋白病期间测定sCD16血清水平发现，与稳定的意义未明的单克隆丙种球蛋白病（MGUS）或对照组相比，多发性骨髓瘤以及迅速进展为多发性骨髓瘤的意义未明的单克隆丙种球蛋白病患者的sCD16血清水平显著降低，这表明该生物学参数具有预后价值。本文描述了sCD16的生物学特性和功能，以及单克隆丙种球蛋白病中sCD16血清水平改变的生物学意义。