TEL融合基因在儿童白血病中的作用。
The role of TEL fusion genes in pediatric leukemias.
作者信息
Rubnitz J E, Pui C H, Downing J R
机构信息
Department of Hematology/Oncology, St Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis 38105-2794, USA.
出版信息
Leukemia. 1999 Jan;13(1):6-13. doi: 10.1038/sj.leu.2401258.
The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. The TEL-AML1 fusion gene, created by the t(12;21), is the most common genetic alteration in childhood acute lymphoblastic leukemia and is associated with a favorable outcome. This review summarizes the roles of the TEL and AML1 proteins in hematopoiesis, the potential transforming mechanisms of TEL fusion proteins, and the clinical significance of the TEL-AML1 fusion.
TEL和AML1基因是造血系统恶性肿瘤中染色体易位的常见靶点。由t(12;21)产生的TEL-AML1融合基因是儿童急性淋巴细胞白血病中最常见的基因改变，且与良好预后相关。本文综述了TEL和AML1蛋白在造血过程中的作用、TEL融合蛋白的潜在转化机制以及TEL-AML1融合的临床意义。
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