铊-201单光子发射计算机断层扫描作为复发性胶质瘤中PCV化疗的反应参数

Thallium-201 SPECT as response parameter for PCV chemotherapy in recurrent glioma.

作者信息

Roesdi M F, Postma T J, Hoekstra O S, van Groeningen C J, Wolbers J G, Heimans J J

机构信息

Dept. of Neurology, University Hospital Vrije Universiteit Amsterdam, The Netherlands.

出版信息

J Neurooncol. 1998 Dec;40(3):251-5. doi: 10.1023/a:1006090807678.

DOI:10.1023/a:1006090807678

PMID:10066098

Abstract

Combination chemotherapy with procarbazine, CCNU and vincristine (PCV) may be effective in patients with recurrent glioma. Response monitoring is mandatory, but radiological response evaluation is often difficult. We evaluated Thallium-201 (201Tl) SPECT as a response parameter in ten patients treated with intensive PCV chemotherapy for recurrent glioma. 201Tl-SPECT studies showed early changes (decreasing volume and intensity) in nine patients and these changes were more pronounced than radiological findings. 201Tl-SPECT results after completion of chemotherapy seemed to correlate with clininal findings during follow up. We conclude that 201Tl-SPECT may contribute to the assessment of response in patients treated with PCV chemotherapy for recurrent glioma.

摘要

丙卡巴肼、洛莫司汀和长春新碱（PCV）联合化疗对复发性胶质瘤患者可能有效。必须进行疗效监测，但放射学疗效评估往往很困难。我们评估了201铊（201Tl）单光子发射计算机断层扫描（SPECT）作为10例接受强化PCV化疗的复发性胶质瘤患者的疗效参数。201Tl-SPECT研究显示9例患者有早期变化（体积和强度减小），且这些变化比放射学检查结果更明显。化疗结束后的201Tl-SPECT结果似乎与随访期间的临床发现相关。我们得出结论，201Tl-SPECT可能有助于评估接受PCV化疗的复发性胶质瘤患者的疗效。