Kotajima N, Kanda T, Sekiguchi K, Tsunoda Y, Osada M, Fukumura Y, Kobayashi I
Department of Laboratory Medicine and Clinical Laboratory Center, Gunma University School of Medicine.
Rinsho Byori. 1999 Jan;47(1):83-8.
The combination of atrial fibrillation (Af) and tricuspid regurgitation (TR) may induce the congestive heart failure (HF) due to insufficient output. However, these associations have not been elucidated. We examined the clinical course with echocardiographic data in 119 patients with Af and/or TR and/or HF. Their mean age was 65 +/- 14 years. The patients were classified into 6 groups as follows: Group I contained patients with Af, TR and HF(n = 13); Group II contained patients with Af and TR, without HF(n = 59); Group III contained patients with TR and HF, without Af(n = 15); Group IV contained patients with TR and without AF and HF(n = 15); Group V contained patients with Af and HF, without TR(n = 24); Group VI contained patients with Af and without TR and HF(n = 13). The fractional shortening and ejection fraction in Group I and II were significantly (p < 0.05) decreased compared to Group IV. Moreover, the fractional shortening in Group V was significantly (p < 0.05) lower than in Group IV. Among 72 cases in Group I and II, 24 cases were followed by echocardiography for 2 to 5 years. Eight cases of HF exhibited a no HF state and 1 demonstrated had the HF state. All 9 cases (38%) showed a decreased heart rate and no alternation of TR. Four of the 24 patients (17%) had developed worsened TR and a lowered ejection fraction but none developed them became HF. Therefore, tachycardia may be an accelerative factor for HF due to the combination of Af and TR, not due to the grade of TR.
心房颤动(Af)与三尖瓣反流(TR)并存可能因心输出量不足而诱发充血性心力衰竭(HF)。然而,这些关联尚未得到阐明。我们通过超声心动图数据研究了119例患有Af和/或TR和/或HF患者的临床病程。他们的平均年龄为65±14岁。患者被分为以下6组:第一组包含患有Af、TR和HF的患者(n = 13);第二组包含患有Af和TR但无HF的患者(n = 59);第三组包含患有TR和HF但无Af的患者(n = 15);第四组包含患有TR但无AF和HF的患者(n = 15);第五组包含患有Af和HF但无TR的患者(n = 24);第六组包含患有Af但无TR和HF的患者(n = 13)。与第四组相比,第一组和第二组的缩短分数和射血分数显著降低(p < 0.05)。此外,第五组的缩短分数显著低于第四组(p < 0.05)。在第一组和第二组的72例病例中,24例接受了2至5年的超声心动图随访。8例HF患者呈现无HF状态,1例仍处于HF状态。所有9例(38%)心率降低且TR无变化。24例患者中有4例(17%)出现TR恶化和射血分数降低,但均未发展为HF。因此,心动过速可能是Af和TR并存导致HF的加速因素,而非TR的严重程度所致。