Ohnishi K
Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Japan.
Am J Trop Med Hyg. 1999 Feb;60(2):248-50. doi: 10.4269/ajtmh.1999.60.248.
Elevated plasma or serum levels of thrombomodulin (TM), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin have been reported in several diseases. However, plasma or serum levels of TM, ICAM-1, VCAM-1, and E-selectin have not been investigated in the acute phase of Plasmodium vivax malaria. Serum TM, ICAM-1, VCAM-1, E-selectin, and creatinine levels were determined in six Japanese patients in the acute phase of vivax malaria and in seven healthy Japanese controls. Parasitemias of the peripheral blood were < 0.1% in five patients and 0.8% in one patient. The patients' mean +/- SD serum levels of TM, ICAM-1, VCAM-1, and E-selectin were 5.7 +/- 1.3 Fujirebio units/ml, 709 +/- 397 ng/ml, 2,112 +/- 782 ng/ml, and 99 +/- 28 ng/ml, respectively, and all were significantly greater than those in the controls (TM; P < 0.005, ICAM-1; P < 0.025, VCAM-1; P < 0.005, E-selectin; P < 0.025). However, no significant difference was identified between patients and controls for serum creatinine values. The serum levels of TM and VCAM-1 were not related to parasitemia. The elevation of serum TM levels suggests that endothelial cell damage occurs in the acute phase of vivax malaria.
在多种疾病中，均有报道血浆或血清中血栓调节蛋白（TM）、细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）和E-选择素水平升高。然而，间日疟原虫疟疾急性期的血浆或血清中TM、ICAM-1、VCAM-1和E-选择素水平尚未得到研究。测定了6例间日疟急性期日本患者和7例健康日本对照者的血清TM、ICAM-1、VCAM-1、E-选择素及肌酐水平。5例患者外周血寄生虫血症<0.1%，1例患者为0.8%。患者血清TM、ICAM-1、VCAM-1和E-选择素的平均±标准差水平分别为5.7±1.3 Fujirebio单位/毫升、709±397纳克/毫升、2112±782纳克/毫升和99±28纳克/毫升，均显著高于对照组（TM；P<0.005，ICAM-1；P<0.025，VCAM-1；P<0.005，E-选择素；P<0.025）。然而，患者与对照组的血清肌酐值无显著差异。血清TM和VCAM-1水平与寄生虫血症无关。血清TM水平升高表明间日疟急性期存在内皮细胞损伤。
