[Expression of human papillomavirus 16, 18 E6 protein of cervical squamous cell carcinoma].

OBJECTIVE

To investigate the expression of human papillomavirus (HPV) 16, 18 E6 protein of cervical squamous cell carcinoma and to assess the practical value of HPV 16, 18 E6 antibody.

METHODS

Immunohistochemistry SP method was used to examine HPV 16, 18 E6 protein expression in 40 cases of squamous cell carcinoma of uterine cerivx, 30 cases of chronic cervicitis and 30 cases of normal cervical epidermal tissue.

RESULTS

27/40 carcinoma cases and 1/30 chronic cervicitis showed positive staining. None of the normal epithelium specimens gave positive results. The difference between malignant and benign groups was significant.

CONCLUSION

A close relation between high risk HPV 16, 18 E6 antibody could be a good indicator for HPV 16, 18 infection and early diagnosis of cervical carcinoma.