神经功能正常儿童脑脊液中神经元特异性烯醇化酶水平

Neuron-specific enolase levels in the cerebrospinal fluid of neurologically healthy children.

作者信息

Rodríguez-Núñez A, Cid E, Eirís J, Rodríguez-García J, Camiña F, Rodríguez-Segade S, Castro-Gago M

机构信息

Department of Pedatrics, Complejo Hospitalario, Universitario de Santiago, Santiago de Compostela, Spain.

出版信息

Brain Dev. 1999 Jan;21(1):16-9. doi: 10.1016/s0387-7604(98)00058-8.

DOI:10.1016/s0387-7604(98)00058-8

PMID:10082247

Abstract

Levels of neuron-specific enolase (NSE) levels in the cerebrospinal fluid (CSF) of children without neurological disease were assessed. CSF samples were obtained from 37 subjects aged between 1 month and 13 years. All subjects had undergone lumbar puncture for diagnostic purposes, and were subsequently shown not to be suffering any form of neurological disease. NSE levels in CSF were determined by an enzyme immunoassay method. NSE level ranged from below the detection limit to 4.8 ng/ml (1.52+/-1.01 ng/ml). The present results may be useful as a basis for defining reference levels of NSE in CSF in post-neonatal children.

摘要

对无神经系统疾病儿童脑脊液（CSF）中神经元特异性烯醇化酶（NSE）水平进行了评估。从37名年龄在1个月至13岁之间的受试者获取了脑脊液样本。所有受试者均因诊断目的接受了腰椎穿刺，随后显示未患有任何形式的神经系统疾病。采用酶免疫测定法测定脑脊液中的NSE水平。NSE水平范围从低于检测限至4.8 ng/ml（1.52±1.01 ng/ml）。本研究结果可作为确定新生儿期后儿童脑脊液中NSE参考水平的依据。