Neu A M, Stablein D M, Zachary A, Furth S L, Fivush B A
Division of Pediatric Nephrology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pediatr Transplant. 1998 Nov;2(4):309-12.
Using the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) database, we performed a retrospective cohort study of 1,552 pediatric renal transplant patients who had received a graft from a biological parent to determine if parental donor sex influences the development of rejection. There were 102/675 (15.1%) graft failures in paternal grafts compared to 144/877 (16.4%) graft failures in maternal grafts. Overall graft survival (p=0.48) and time to first rejection (p>0.9) were not different in patients receiving paternal versus maternal grafts. The overall frequency of graft loss to rejection was also not different. However, maternal donation was associated with a significantly longer time to first rejection in patients less than one year of age at the time of transplantation (p=0.01). Time to first rejection was not different between maternal and paternal grafts in older recipients. In summary, the present study did not demonstrate a difference in graft survival between maternal and paternal donations, but the youngest patients may experience a longer time to first rejection with maternal donation. The number of young patients is small, however, and further data are necessary to confirm this observation.
利用北美儿科肾移植协作研究（NAPRTCS）数据库，我们对1552名接受亲生父母活体供肾移植的儿科肾移植患者进行了一项回顾性队列研究，以确定供肾父母的性别是否会影响排斥反应的发生。父源供肾移植有102例失败，共675例移植（失败率15.1%），母源供肾移植有144例失败，共877例移植（失败率16.4%）。接受父源与母源供肾移植的患者，总体移植存活率（p = 0.48）和首次排斥反应发生时间（p > 0.9）并无差异。因排斥反应导致移植肾丢失的总体频率也无差异。然而，对于移植时年龄小于1岁的患者，母源供肾与首次排斥反应发生时间显著延长相关（p = 0.01）。年龄较大的受者中，母源与父源供肾的首次排斥反应发生时间无差异。总之，本研究未显示母源和父源供肾在移植存活率上存在差异，但年龄最小的患者接受母源供肾时首次排斥反应发生时间可能更长。不过，年轻患者数量较少，需要更多数据来证实这一观察结果。
