宫内生长受限中的母体、胎儿及产后生长激素轴

The maternal, fetal and postnatal somatotrophic axes in intrauterine growth retardation.

作者信息

Oliver M H, Bloomfield F H, Harding J E, Breier B H, Bassett N S, Gluckman P D

机构信息

Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand.

出版信息

Biochem Soc Trans. 1999 Feb;27(2):69-73. doi: 10.1042/bst0270069.

DOI:10.1042/bst0270069

PMID:10093709

Abstract

Both the maternal and fetal somatotrophic axes are closely linked to fetal substrate supply. Nutritional insults at critical stages of fetal development may lead to permanent reprogramming of the relationships between these factors. The consequences of reprogramming during fetal life may be harmful to metabolic, endocrine and cardiovascular homoeostatic mechanisms in postnatal life. The exact mechanisms that lead to reprogramming during fetal life need thorough investigation before effective strategies to deal with this problem can be devised.

摘要

母体和胎儿的生长激素轴均与胎儿底物供应密切相关。胎儿发育关键阶段的营养损伤可能导致这些因素之间关系的永久性重新编程。胎儿期重新编程的后果可能对出生后生活中的代谢、内分泌和心血管稳态机制有害。在制定有效应对这一问题的策略之前，导致胎儿期重新编程的确切机制需要深入研究。