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精神分裂症中自知力及自知力变化的相关因素

Correlates of insight and insight change in schizophrenia.

作者信息

Carroll A, Fattah S, Clyde Z, Coffey I, Owens D G, Johnstone E C

机构信息

Department of Psychiatry, University of Edinburgh, UK.

出版信息

Schizophr Res. 1999 Feb 15;35(3):247-53. doi: 10.1016/s0920-9964(98)00142-x.

Abstract

Various theories have been proposed to account for poor insight in schizophrenia. This study examined the relationships between insight, mood, schizophrenic symptoms and cognitive functioning. The relationship between longitudinal changes in insight and changes in symptoms and mood was also investigated. One-hundred patients with DSM-III-R schizophrenia, recently recovered from a relapse of their illness, were rated on the Insight and Treatment Attitudes Questionnaire (ITAQ), the Positive and Negative Syndrome Scale (PANSS), the Montgomery Asberg Depression Rating Scale (MADRS), the Rivermead Behavioural Memory Test and tests of current and premorbid IQ. A random sample of 53 were then given an educational package (video and booklets) designed to improve their insight. Follow-up ratings on the ITAQ, PANSS and MADRS were subsequently obtained. At baseline, better insight was significantly correlated with lower mood and fewer positive symptoms. It was not related to cognitive functioning. Improvement in insight at follow up was related to worsening of mood, but not to change in positive symptoms. The results are consistent with the concept that poor insight, at least in part, results from the psychotic disease process itself. In addition, they suggest that poor insight may protect against depression in the early stages of recovery from schizophrenia.

摘要

针对精神分裂症自知力缺失,人们提出了各种理论。本研究探讨了自知力、情绪、精神分裂症症状与认知功能之间的关系。同时也研究了自知力的纵向变化与症状及情绪变化之间的关系。对100例近期从疾病复发中康复的DSM-III-R精神分裂症患者,采用自知力与治疗态度问卷(ITAQ)、阳性和阴性症状量表(PANSS)、蒙哥马利-阿斯伯格抑郁评定量表(MADRS)、里弗米德行为记忆测试以及当前和病前智商测试进行评定。然后从这100例患者中随机抽取53例,给予一套旨在提高其自知力的教育资料(视频和小册子)。随后对ITAQ、PANSS和MADRS进行随访评定。在基线时,较好的自知力与较低的情绪及较少的阳性症状显著相关。它与认知功能无关。随访时自知力的改善与情绪恶化有关,但与阳性症状的变化无关。这些结果与以下观点一致,即自知力缺失至少部分是由精神病性疾病过程本身导致的。此外,它们表明自知力缺失可能在精神分裂症康复早期预防抑郁。

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