Schiwy-Bochat K H, Lemke R
Institute of Forensic Medicine, Aachen University of Technology, Germany.
J Forensic Sci. 1999 Mar;44(2):249-52.
Histomorphometry was used to determine structural bone changes in drug addicts. Iliac crest bone biopsies were obtained at autopsy from 28 subjects (21 male, 7 female, aged 18 to 45 years) who had a history of drug abuse and had died due to overdose of illicit drugs. For histomorphometry, undecalcified sections were investigated using the Merz grid. The following histomorphometric indices were measured and calculated: BV/TV, BS/BV, Tb.Th, Tb.N, Tb.Sp, OV/TV, OS/BS, Ob.S/BS, O.Th, ES/BS, Oc.S/BS, and N.Oc/T.A. In 28 controls (24 male, 4 female, aged 17 to 47 years) trabecular bone specimens were investigated in the same way. The parameters in drug addicts did not show any correlation to age, body weight, height or sex differences. Trabecular bone volume and trabecular thickness were slightly but not significantly increased (BV/TV: 23.37 +/- 5.77% (mean, SD), controls 22.23 +/- 5.08%, p = 0.434; Tb.Th: 172.67 +/- 36.83 mcm, controls 169.73 +/- 36.13 mcm, p = 0.764). Only the eroded surface was significantly different to the controls (ES/BS: 8.16 +/- 2.04%, controls 6.96 +/- 2.17%, p = 0.038). We conclude that the incidence of metabolic bone disease in drug addicts is low.
采用组织形态计量学方法来确定吸毒者骨骼结构的变化。从28名有药物滥用史且死于非法药物过量的受试者（21名男性，7名女性，年龄在18至45岁之间）尸检时获取髂嵴骨活检标本。对于组织形态计量学，使用Merz网格对未脱钙切片进行研究。测量并计算了以下组织形态计量学指标：骨体积分数（BV/TV）、骨表面积与骨体积之比（BS/BV）、骨小梁厚度（Tb.Th）、骨小梁数量（Tb.N）、骨小梁间距（Tb.Sp）、骨体积分数（OV/TV）、骨表面积与骨体积之比（OS/BS）、破骨细胞表面积与骨表面积之比（Ob.S/BS）、破骨细胞厚度（O.Th）、侵蚀表面积与骨表面积之比（ES/BS）、骨吸收陷窝表面积与骨表面积之比（Oc.S/BS）以及每单位组织面积的破骨细胞数量（N.Oc/T.A）。对28名对照者（24名男性，4名女性，年龄在17至47岁之间）的小梁骨标本进行了同样的研究。吸毒者的这些参数与年龄、体重、身高或性别差异均无相关性。小梁骨体积和小梁厚度略有增加但不显著（BV/TV：23.37±5.77%（平均值，标准差），对照组为22.23±5.08%，p = 0.434；Tb.Th：172.67±36.83μm，对照组为169.73±36.13μm，p = 0.764）。只有侵蚀表面积与对照组有显著差异（ES/BS：8.16±2.04%，对照组为6.96±2.17%，p = 0.038）。我们得出结论，吸毒者代谢性骨病的发生率较低。
