Nel T, Joubert G, van der Ryst E, Bester I
Department of Haematology, Faculty of Health Sciences, University of the Orange Free State, Bloemfontein, South Africa.
Cent Afr J Med. 1998 Aug;44(8):195-9.
To study the clinical presentation, treatment and outcome of patients diagnosed with chronic lymphocytic leukaemia (CLL) in the Bloemfontein academic hospitals during the past 21 years.
Descriptive, retrospective study of clinical records of all CLL patients diagnosed at the Haematology clinics of the Universitas and Pelonomi Hospitals in Bloemfontein from 1975 to 1996.
Age, sex and race distribution of CLL patients were analysed. The peripheral blood, bone marrow, clinical presentation and stage at time of diagnosis, were studied. Treatment modalities, response to treatment and survival of patients were also analysed. Categorical variables were summarised by frequencies and percentages, and numerical variables by means of percentiles. Subgroup comparisons were done by 95% confidence intervals (CI) for differences in percentages, medians or means.
A total of 185 CLL patients were studied. There were more males (62.7%) than females and the mean age of the patients was 63 years (19 to 98 years). Eighty six percent of the patients were older than 50 years. Racial distribution was as follow: 106 White, 77 Black and two patients of mixed race. Black patients more often presented with advanced disease and higher lymphocyte counts. A response to therapy was noted for 118 (82.5%) of the 143 patients who received treatment. A complete remission or partial response was noted for 38 (32.2%) of the patients.
The presentation of CLL in the Bloemfontein academic hospitals is similar to what is seen world-wide. This is the first study describing CLL in a large number of Black patients and demonstrates that although Black patients presented more often at a younger age and had high risk disease, their clinical course and progression according to stage, also correlated with what is described in the literature.
研究过去21年中在布隆方丹学术医院被诊断为慢性淋巴细胞白血病（CLL）的患者的临床表现、治疗及预后情况。
对1975年至1996年期间在布隆方丹大学医院和佩洛诺米医院血液科诊所确诊的所有CLL患者的临床记录进行描述性回顾性研究。
分析CLL患者的年龄、性别和种族分布情况。研究患者诊断时的外周血、骨髓、临床表现及分期。分析治疗方式、治疗反应及患者生存率。分类变量用频率和百分比进行总结，数值变量用百分位数表示。通过95%置信区间（CI）对百分比、中位数或均值的差异进行亚组比较。
共研究了185例CLL患者。男性患者（62.7%）多于女性，患者平均年龄为63岁（19至98岁）。86%的患者年龄超过50岁。种族分布如下：106例白人，77例黑人，2例混血患者。黑人患者更常表现为疾病进展且淋巴细胞计数更高。143例接受治疗的患者中有118例（82.5%）对治疗有反应。38例（32.2%）患者达到完全缓解或部分缓解。
布隆方丹学术医院CLL的表现与全球所见相似。这是第一项描述大量黑人患者CLL的研究，表明尽管黑人患者发病年龄更年轻且疾病风险高，但他们根据分期的临床病程和进展情况也与文献报道相符。
