Conte A, Pizá P, García-Raja A
Servicio de Urologío, Servicio de Análisis Clínicos, Hospital Universitario Son Dureta, Palma de Mallorca, Spain.
Arch Esp Urol. 1999 Jan-Feb;52(1):94-9.
This paper presents the results of a test to globally determine the urinary risk factor of calcium stone formation in the evaluation of treatments using crystallization inhibitors, such as citrate and phytate.
Three groups of active calcium oxalate stone-formers have been selected. The lithogen urinary risk was determined using a specially designed disposable test before any medical treatment. After evaluation group I did not receive any treatment, group II was treated with potassium citrate and group III with a phytate-rich dietary complement. When 15 days had elapsed, the test to evaluate the risk of urinary calcium stone formation was applied again to the three groups. The main lithogenic biochemical parameters of each tested urine were also determined before and after treatment.
An important number of calcium oxalate stone-formers with high urinary risk factor (positive test) became negative after medical treatment (52% of the citrate-treated patients and 50% of the phytate-treated patients), but only 7% of the untreated patients (1 patient) showed a decrease in their urinary risk factor for calcium stones (negative test) after 15 days had elapsed. When the treatment was not effective, in an important number of cases, the urine contained high levels of calcium or showed pH values greater than 6.5.
From the obtained results it can be concluded that the test is useful to evaluate the efficacy of a given renal lithiasis medical treatment, and also the efficacy of the treatment of calcium oxalate renal lithiasis using crystallization inhibitors, such as citrate and phytate, in an important number of cases.
本文介绍了一项测试的结果，该测试旨在全面确定在使用结晶抑制剂（如柠檬酸盐和植酸盐）进行治疗评估时钙结石形成的尿液风险因素。
选择了三组活性草酸钙结石形成者。在任何医学治疗之前，使用专门设计的一次性测试来确定结石形成的尿液风险。评估后，第一组未接受任何治疗，第二组用柠檬酸钾治疗，第三组用富含植酸盐的饮食补充剂治疗。15天后，再次对三组进行评估尿钙结石形成风险的测试。还在治疗前后测定了每次测试尿液的主要结石形成生化参数。
大量具有高尿液风险因素（测试阳性）的草酸钙结石形成者在医学治疗后变为阴性（52%的柠檬酸盐治疗患者和50%的植酸盐治疗患者），但只有7%的未治疗患者（1名患者）在15天后显示其钙结石尿液风险因素降低（测试阴性）。当治疗无效时，在许多情况下，尿液中钙含量高或pH值大于6.5。
从获得的结果可以得出结论，该测试可用于评估给定肾石病医学治疗的疗效，以及在许多情况下使用结晶抑制剂（如柠檬酸盐和植酸盐）治疗草酸钙肾石病的疗效。
