Bosova N N
Biull Eksp Biol Med. 1976;82(11):1377-9.
Whole gastrocnemius muscles, preliminarily (one month before) denervated, were auto- and homotransplanted in dogs. The transplanted muscles took at the site of transplantation; some of the transplanted material was lost and was resorbed; myoblasts were released from the viable disintegrating material. The muscle organ was built anew as a result of further differentiation of myogenic elements in the autotransplants under conditions of timely restoration of the circulation and innervation. No stable take of the transplant occurred in the case of homoplasty--the newlyformed muscle was lost as a result of the incompatibility reaction. Thus, preliminary denervation serves as an effective means of preparation of the muscle tissue for the autotransplantation.
将预先(在一个月前)去神经支配的完整腓肠肌进行自体移植和同种异体移植到狗身上。移植的肌肉在移植部位存活;部分移植组织丢失并被吸收;成肌细胞从存活的崩解组织中释放出来。在循环和神经支配及时恢复的条件下,自体移植中肌源性成分进一步分化,肌肉器官得以重新构建。在同种异体移植的情况下,移植组织未能稳定存活——由于不相容反应,新形成的肌肉丢失了。因此,预先去神经支配是肌肉组织自体移植的一种有效预处理方法。