特发性胆汁酸腹泻
Idiopathic bile acid catharsis.
作者信息
Thaysen E H, Pedersen L
出版信息
Gut. 1976 Dec;17(12):965-70. doi: 10.1136/gut.17.12.965.
Abstract
In the course of extensive routine screening for bile acid malabsorption a few patients were detected in whom chronic diarrhoea was apparently induced by excess bile acid loss which was neither associated with demonstrable conventional ileopathy nor with any other disorder allied to diarrhoea. In three patients subjected to scrutiny the results obtained were in harmony with a concept of idiopathic bile acid catharsis. Ingestion of cholestyramine was followed by immediate relief, but the diarrhoea recurred whenever this treatment was withdrawn. It it suggested that idiopathic bile acid catharsis should be suspected in patients with unexplained chronic diarrhoea and especially in those with a diagnosis of irritable colon with diarrhoea.
摘要
在对胆汁酸吸收不良进行广泛常规筛查的过程中，发现了少数患者，其慢性腹泻显然是由胆汁酸过度流失引起的，这既与可证实的传统回肠病无关，也与任何其他与腹泻相关的疾病无关。在接受详细检查的三名患者中，所获得的结果与特发性胆汁酸导泻的概念相符。服用消胆胺后症状立即缓解，但每次停止这种治疗时腹泻都会复发。建议对于原因不明的慢性腹泻患者，尤其是诊断为腹泻型肠易激综合征的患者，应怀疑特发性胆汁酸导泻。
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