Fukamauchi F, Aihara O, Kusakabe M
Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Neuropeptides. 1998 Jun;32(3):265-8. doi: 10.1016/s0143-4179(98)90046-4.
Tenascin-C (TN), an extracellular matrix glycoprotein which reveals both neurite outgrowth-promoting and growth-inhibiting effects, is generated in the central nervous system. A previous study reported that TN-gene null mutant mice display hyperlocomotion and do not easily habituate to unfamiliar environments. Additionally, these mice display poor appetite, abnormal circadian rhythm and low pregnancy rate. The present study demonstrated that neuropeptide Y (NPY) mRNA expression is reduced in the limbic area of the TN gene-deficient mouse brain as compared to wild-type mice. NPY has been shown to affect emotion, circadian rhythm and food intake, and the present results suggest that the some behavioural abnormalities exhibited by TN-mutant mice may be in part due to the low level of expression of NPY mRNA in the limbic system.
腱生蛋白-C（TN）是一种细胞外基质糖蛋白，在中枢神经系统中产生，具有促进神经突生长和抑制生长的双重作用。先前的一项研究报告称，TN基因敲除突变小鼠表现出运动亢进，且不容易适应陌生环境。此外，这些小鼠食欲不佳、昼夜节律异常且妊娠率低。本研究表明，与野生型小鼠相比，TN基因缺陷小鼠大脑边缘区域的神经肽Y（NPY）mRNA表达降低。NPY已被证明会影响情绪、昼夜节律和食物摄入，目前的结果表明，TN突变小鼠表现出的一些行为异常可能部分归因于边缘系统中NPY mRNA表达水平较低。
