成纤维细胞生长因子受体（FGFRs）及其在肢体发育中的作用。

Fibroblast growth factor receptors (FGFRs) and their roles in limb development.

作者信息

Xu X, Weinstein M, Li C, Deng C

机构信息

Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, 10/9N105, 10 Center Drive, Bethesda, MD 20892, USA.

出版信息

Cell Tissue Res. 1999 Apr;296(1):33-43. doi: 10.1007/s004410051264.

DOI:10.1007/s004410051264

PMID:10199963

Abstract

Fibroblast growth factor (FGF) receptors constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). To study functions of FGF/ FGFR signals in development, mice that carry mutations in each receptor have been created by gene targeting. Analysis of these mutant mice revealed essential functions of FGF receptors in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. In this review we discuss recent work with FGF receptors to illustrate mechanisms, through which the FGF/FGFR signals specify vertebrate limb initiation, outgrowth and patterning.

摘要

成纤维细胞生长因子（FGF）受体构成了一个由四个跨膜酪氨酸激酶（FGFR1 - 4）组成的家族，它们作为17种生长因子（FGF1 - 17）的高亲和力受体。为了研究FGF/FGFR信号在发育过程中的功能，通过基因靶向技术创建了每个受体携带突变的小鼠。对这些突变小鼠的分析揭示了FGF受体在多个生物学过程中的重要功能，包括中胚层诱导和模式形成、细胞生长和迁移、器官形成以及骨骼生长。在这篇综述中，我们讨论了最近关于FGF受体的研究工作，以阐明FGF/FGFR信号指定脊椎动物肢体起始、生长和模式形成的机制。