Hummer M, Kemmler G, Kurz M, Kurzthaler I, Oberbauer H, Fleischhacker W W
Department of Biological Psychiatry, Innsbruck University Clinics, Austria.
Am J Psychiatry. 1999 Apr;156(4):631-3. doi: 10.1176/ajp.156.4.631.
The aim of this study was to evaluate the frequency and course of sexual disturbances associated with clozapine and haloperidol and their potential influence on compliance with medication regimens in patients with schizophrenia.
The authors prospectively investigated 153 patients with schizophrenia who received clozapine (N = 100) or haloperidol (N = 53) in a drug monitoring program.
The frequency of sexual disturbances was lower in female patients than in male patients. There was no statistically significant difference between the patients taking haloperidol and those taking clozapine in the frequency of these disturbances. Clozapine plasma levels had a significant effect on diminished sexual desire and functional disturbances in male patients. Functional disturbances and diminished sexual desire did not have any influence on compliance in patients taking either haloperidol or clozapine.
There was no statistically significant difference between haloperidol and clozapine in regard to their propensity to induce sexual side effects.
本研究旨在评估与氯氮平和氟哌啶醇相关的性功能障碍的发生率和病程，以及它们对精神分裂症患者药物治疗依从性的潜在影响。
作者在一个药物监测项目中对153例接受氯氮平（N = 100）或氟哌啶醇（N = 53）治疗的精神分裂症患者进行了前瞻性研究。
女性患者性功能障碍的发生率低于男性患者。服用氟哌啶醇的患者和服用氯氮平的患者在这些障碍的发生率上没有统计学上的显著差异。氯氮平血浆水平对男性患者性欲减退和性功能障碍有显著影响。性功能障碍和性欲减退对服用氟哌啶醇或氯氮平的患者的依从性没有任何影响。
氟哌啶醇和氯氮平在引起性副作用的倾向方面没有统计学上的显著差异。
