神经肽Y：消耗性疾病中厌食和恶病质的关键分子？
Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?
作者信息
Inui A
机构信息
Second Dept of Internal Medicine, Kobe University School of Medicine, Japan.
出版信息
Mol Med Today. 1999 Feb;5(2):79-85. doi: 10.1016/s1357-4310(98)01395-1.
Abstract
Anorexia and body weight loss are characteristic of many diseases, including cancer and AIDS. Recent studies indicate that inflammatory cytokines, such as interleukin 1, the interleukin 6 subfamily and tumor necrosis factor, induce anorexia and cachexia by inhibiting the normal adaptive feeding response to energy deficits. Here, I discuss the evidence for and against a central role for neuropeptide Y and leptin in anorexia and cachexia.
摘要
厌食和体重减轻是许多疾病的特征，包括癌症和艾滋病。最近的研究表明，炎性细胞因子，如白细胞介素1、白细胞介素6亚家族和肿瘤坏死因子，通过抑制对能量缺乏的正常适应性进食反应来诱导厌食和恶病质。在此，我讨论支持和反对神经肽Y和瘦素在厌食和恶病质中起核心作用的证据。
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