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[使用动脉血管进行心肌血运重建:双侧乳内动脉与单侧乳内动脉的比较]

[Myocardial revascularization with arterial conduits: comparison of bilateral internal mammary artery and single internal mammary artery].

作者信息

Codecasa R, Milano A, De Carlo M, Levantino M, Tartarini G, Nardi C, Magagnini E, Bortolotti U

机构信息

Cattedra di Cardiochirurgia, Università degli Studi.

出版信息

Cardiologia. 1999 Feb;44(2):169-75.

Abstract

The use of bilateral internal mammary artery (BIMA) grafting for myocardial revascularization has been demonstrated to provide long-term benefits compared to revascularization using single left internal mammary artery (SIMA) and venous conduits. However, it is still controversial whether the use of BIMA is associated with a higher hospital mortality and morbidity. The present study retrospectively evaluated the possible advantages related to the use of BIMA at 3-year follow-up and whether the presence of operative risk factors in patients with BIMA could limit the application of the procedure in myocardial revascularization. We compared two groups of 100 patients matched for preoperative clinical characteristics, who underwent myocardial revascularization on the left coronary system with BIMA (93 males and 7 females, mean age 59 +/- 4 years) or with SIMA and venous conduits (86 males and 14 females, mean age 63 +/- 6 years). Hospital mortality rate was 2% in both groups, the use of BIMA being not a significant risk factor for hospital mortality and morbidity. The mean follow-up was 36 +/- 6 months for the BIMA group and 40 +/- 10 months for the SIMA group. At 3 years, there was no significant differences in the actuarial freedom from cardiac death (96 +/- 2% for BIMA vs 94 +/- 2% for SIMA patients), myocardial infarction (98 +/- 2 vs 97 +/- 2%), angina (93 +/- 2 vs 91 +/- 2%), symptomatic heart failure (92 +/- 3 vs 92 +/- 2%), coronary angioplasty/reoperation (96 +/- 2 vs 97 +/- 2% ), and total cardiac events (80 +/- 4 vs 76 +/- 4%). BIMA grafting was not an independent predictor of late cardiac events. In 66 patients who underwent a late angiographic or echo-Doppler study, the patency rate was 100% for the left mammary artery, 94% for the right mammary artery and 69% for venous conduits. In conclusion, myocardial revascularization with BIMA in situ is associated with low hospital mortality and morbidity, good clinical outcome and excellent patency rate at 3 years, with apparently no significant differences when compared to the use of SIMA and venous conduits. The low hospital mortality and morbidity and the satisfactory medium-term results in our opinion justify a more extensive use of BIMA in myocardial revascularization.

摘要

与使用单根左乳内动脉(SIMA)和静脉导管进行血运重建相比,采用双侧乳内动脉(BIMA)移植进行心肌血运重建已被证明可带来长期益处。然而,使用BIMA是否会导致更高的医院死亡率和发病率仍存在争议。本研究回顾性评估了在3年随访期内使用BIMA的可能优势,以及BIMA患者中手术风险因素的存在是否会限制该手术在心肌血运重建中的应用。我们比较了两组术前临床特征匹配的100例患者,一组采用BIMA对左冠状动脉系统进行心肌血运重建(93例男性和7例女性,平均年龄59±4岁),另一组采用SIMA和静脉导管进行心肌血运重建(86例男性和14例女性,平均年龄63±6岁)。两组的医院死亡率均为2%,使用BIMA并非医院死亡率和发病率的显著风险因素。BIMA组的平均随访时间为36±6个月,SIMA组为40±10个月。在3年时,心脏死亡的精算自由度(BIMA患者为96±2%,SIMA患者为94±2%)、心肌梗死(98±2对97±2%)、心绞痛(93±2对91±2%)、有症状心力衰竭(92±3对92±2%)、冠状动脉血管成形术/再次手术(96±2对97±2%)以及总心脏事件(80±4对76±4%)方面均无显著差异。BIMA移植并非晚期心脏事件的独立预测因素。在66例接受晚期血管造影或超声多普勒研究的患者中,左乳内动脉的通畅率为100%,右乳内动脉为94%,静脉导管为69%。总之,原位BIMA心肌血运重建与低医院死亡率和发病率、良好的临床结局以及3年时出色的通畅率相关,与使用SIMA和静脉导管相比显然无显著差异。我们认为,低医院死亡率和发病率以及令人满意的中期结果证明在心肌血运重建中更广泛地使用BIMA是合理的。

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