表皮生长因子受体：多种受体途径的关键介质。
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
作者信息
Hackel P O, Zwick E, Prenzel N, Ullrich A
机构信息
Department of Molecular Biology, Max Planck Institut für Biochemie, AmKlopferspitz 18A, 82152 Martinsried, Germany.
出版信息
Curr Opin Cell Biol. 1999 Apr;11(2):184-9. doi: 10.1016/s0955-0674(99)80024-6.
Recently, the receptor for epidermal growth factor (EGF) was identified as a downstream element in different signaling pathways. This expanded its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network. In addition, several downstream targets, (e.g. Smad proteins and STATs) into which signals from synergistic and antagonistic signaling pathways converge, were identified.
最近，表皮生长因子（EGF）受体被确定为不同信号通路中的下游元件。这将其作为EGF样配体受体的经典功能扩展到作为多种信号系统的介质以及细胞通信网络的切换点的作用。此外，还确定了协同和拮抗信号通路的信号汇聚到的几个下游靶点（例如Smad蛋白和信号转导子和转录激活子）。
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