Taniguchi K, Okamura K, Hayashi M, Funakoshi T, Motokawa W
Department of Oral Pathology, Fukuoka Dental College, Japan.
Endod Dent Traumatol. 1999 Feb;15(1):17-25. doi: 10.1111/j.1600-9657.1999.tb00743.x.
Intrusive trauma was experimentally applied to the tooth germ at different developmental stages in the rat first molar. The tooth germ at the earliest (postnatal day 1, initiating stage of enamel matrix formation) and the latest (postnatal day 10, calcifying stage of preformed enamel matrix) developmental stages studied showed localized enamel hypoplasia as a direct sequela of trauma. The tooth germs in which enamel matrix was rapidly thickening (postnatal days 3, 5, 7) and had not yet started to calcify showed the most intense and extensive injuries to the formation and structural organization of both enamel and dentin. As for indirect effects secondary to trauma, tooth germ dislocation was observed chiefly in tooth germs at the same developmental stages, frequently resulting in ankylosis. The present experimental model may be helpful for clarifying the histogenesis of traumatic changes in the developing tooth germ.
在大鼠第一磨牙的不同发育阶段，通过实验对牙胚施加侵入性创伤。研究中最早（出生后第1天，釉质基质形成起始阶段）和最晚（出生后第10天，预成釉质基质钙化阶段）发育阶段的牙胚出现局部釉质发育不全，这是创伤的直接后遗症。釉质基质迅速增厚（出生后第3、5、7天）且尚未开始钙化的牙胚，其釉质和牙本质的形成及结构组织受到的损伤最为严重和广泛。至于创伤的间接影响，主要在相同发育阶段的牙胚中观察到牙胚脱位，常导致牙齿固连。本实验模型可能有助于阐明发育中牙胚创伤性变化的组织发生过程。
