Caparelli-Dáquer E M, Schmidt S L
Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Brazil.
Int J Dev Neurosci. 1999 Feb;17(1):67-77. doi: 10.1016/s0736-5748(98)00060-4.
We have previously suggested a relationship between the development of the corpus callosum and the direction of cerebral asymmetries (Schmidt and Caparelli-Daquer, 1989; Schmidt et al., 1991). Here we report a study on morphological brain asymmetries using a distinct experimental approach. At embryonic day 16, mice were exposed to a gamma source, receiving a total dose of 2 Gy. At adulthood 32 irradiated and 28 normal male Swiss mice were evaluated for individual and populational interhemispheric asymmetries of weight, dorsal area, and neocortical volume. All irradiated mice showed callosal defects ranging from total absence to a partial reduction of the midsagittal callosal area. The normal and irradiated groups displayed a pronounced individual asymmetry in all measurements. In contrast, populational asymmetry could be identified only in the normal group. These results are consistent with our previous data in acallosal mutant mice and support the hypothesis that the corpus callosum may play a role in directing interhemispheric morphological brain asymmetries.
我们之前曾提出胼胝体发育与大脑不对称方向之间的关系（施密特和卡帕雷利 - 达克，1989年；施密特等人，1991年）。在此，我们报告一项采用独特实验方法对大脑形态不对称性进行的研究。在胚胎第16天，将小鼠暴露于γ源，接受的总剂量为2戈瑞。成年后，对32只受辐照和28只正常雄性瑞士小鼠的体重、背侧面积和新皮质体积的个体及群体半球间不对称性进行评估。所有受辐照小鼠均表现出胼胝体缺陷，从中矢状胼胝体区域完全缺失到部分缩小不等。正常组和受辐照组在所有测量中均表现出明显的个体不对称性。相比之下，仅在正常组中可识别出群体不对称性。这些结果与我们之前在无胼胝体突变小鼠中的数据一致，并支持胼胝体可能在引导半球间大脑形态不对称性方面发挥作用的假说。
