Hashimoto I, Ichida F, Tsubata S, Hamamichi Y, Uese K, Miyazaki A, Miyawaki T
Department of Pediatrics, Toyama Medical Pharmaceutical University, Japan.
Pediatr Int. 1999 Apr;41(2):126-31. doi: 10.1046/j.1442-200x.1999.4121047.x.
Measurement of left ventricular mass (LVM) is important to the diagnosis of left ventricular hypertrophy in children with various cardiovascular diseases. The purpose of this study was to determine the most appropriate method for standardization of LVM and to evaluate obesity-induced left ventricular hypertrophy in children across the entire age range, from infancy through adolescence.
We studied 928 children and adolescents (527 males, 401 females), aged 0-17 years, who were classified into two groups by degree of obesity. Left ventricular mass was calculated by M-mode echocardiography using the formula of Devereux et al. and was indexed using body size (body length, bodyweight or body surface area) raised to a non-integer power using logarithmic transformation of measurements in children without obesity.
The body length, bodyweight and body surface area exponents were 1.85, 0.88 and 1.15, respectively, in males, and 1.72, 0.82 and 1.08, respectively, in females. Whereas indexing of left ventricular mass by body length both in males and in females revealed significant differences between the two groups, indexing using bodyweight or body surface area exponents did not manifest left ventricular hypertrophy induced by obesity.
It is suggested that applying body length exponents 1.85 in males and 1.72 in females is an appropriate method for indexation of LVM in children and adolescents. This method is particularly useful for the evaluation of left ventricular hypertrophy in children.
测量左心室质量（LVM）对于诊断患有各种心血管疾病的儿童的左心室肥厚很重要。本研究的目的是确定LVM标准化的最合适方法，并评估从婴儿期到青春期整个年龄范围内肥胖引起的儿童左心室肥厚。
我们研究了928名0至17岁的儿童和青少年（527名男性，401名女性），根据肥胖程度将其分为两组。使用Devereux等人的公式通过M型超声心动图计算左心室质量，并使用无肥胖儿童测量值的对数转换将身体大小（身长、体重或体表面积）提升到非整数幂来进行指数化。
男性的身长、体重和体表面积指数分别为1.85、0.88和1.15，女性分别为1.72、0.82和1.08。尽管男性和女性使用身长对左心室质量进行指数化显示两组之间存在显著差异，但使用体重或体表面积指数并未显示出肥胖引起的左心室肥厚。
建议应用男性为1.85、女性为1.72的身长指数作为儿童和青少年LVM指数化的合适方法。该方法对于评估儿童左心室肥厚特别有用。
