Hellström A, Wiklund L M, Svensson E
Department of Clinical Neurosciences, International Paediatric Growth Research Centre, Sahlgrenska University Hospital, Göteborg, Sweden.
J AAPOS. 1999 Apr;3(2):104-8. doi: 10.1016/s1091-8531(99)70079-0.
This study set out to evaluate magnetic resonance imaging (MRI) and measurement of optic disc size as diagnostic tools for confirming the diagnosis of optic nerve hypoplasia (ONH) in children with impaired growth.
MRI was performed to study the size of the intracranial visual pathways, and image analysis measurements of fundus photographs were performed to determine the size of the optic disc. Results from these investigations were compared with those using the gold standard for diagnosis of ONH, which was the clinical eye examination (visual function, ophthalmoscopic signs, or both). Forty children (median age, 9 years; range, 3 to 19 years) with impaired growth were included in the study.
The prevalence of ONH among the children was 15%. MRI classification of the visual pathways had a higher positive predictive value than image analysis measurement of the optic disc size (1.0 vs 0.6).
MRI is a good tool for confirming the diagnosis of ONH and may thus facilitate early detection. On the other hand, a small optic disc per se is not a definite indicator of ONH but should encourage further investigation with MRI, especially if there is a clinical suspicion of ONH.
本研究旨在评估磁共振成像（MRI）和视盘大小测量作为诊断工具，用于确诊生长发育迟缓儿童的视神经发育不全（ONH）。
进行MRI以研究颅内视觉通路的大小，并对视盘照片进行图像分析测量以确定视盘大小。将这些研究结果与使用ONH诊断金标准（临床眼部检查，包括视觉功能、检眼镜检查体征或两者）的结果进行比较。40名生长发育迟缓儿童（中位年龄9岁；范围3至19岁）纳入本研究。
儿童中ONH的患病率为15%。视觉通路的MRI分类比视盘大小的图像分析测量具有更高的阳性预测值（1.0对0.6）。
MRI是确诊ONH的良好工具，因此可能有助于早期检测。另一方面，视盘小本身并非ONH的确切指标，但应促使进一步进行MRI检查，尤其是在临床怀疑有ONH时。
Zotero 插件