Kalafatis P, Zarifis I, Sotrillis T, Stefis A
Clinica di Urologia, Ospedale Generale, Rodi, Grecia.
Minerva Urol Nefrol. 1999 Mar;51(1):45-8.
A rare case of mucinous adenocarcinoma of the renal pelvis associated with renal staghorn calculosis in a 60-years-old male patient with pyuria and mucin content of the urine is presented. History was significant for recurrent calculosis of the left kidney. A non functioning hydronephrotic left kidney with staghorn calculosis was diagnosed. Laboratory tests were remarkable only for Carcinoembrionic Antigen (CEA). Pathology of the surgical specimen followed by its immunoreactivity revealed an intestinal type metaplasia and papillary, tubular and mucinous adenocarcinoma of the renal pelvis. Pathogenesis of the intestinal metaplasia and the role of chronic irritation of the urothelium are mentioned.
本文报道了一例60岁男性肾盂黏液腺癌合并肾鹿角形结石病的罕见病例,该患者有脓尿且尿液中含有黏液。病史显示左肾反复出现结石病。诊断为左肾无功能肾积水伴鹿角形结石。实验室检查仅癌胚抗原(CEA)异常。手术标本的病理检查及其免疫反应显示为肠化生以及肾盂乳头状、管状和黏液腺癌。文中提到了肠化生的发病机制以及尿路上皮慢性刺激的作用。