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[碳酸盐矿泉浴对缺血性脑损伤的神经保护作用机制]

[The mechanisms of the neuroprotective action of carbonate mineral baths in ischemic brain lesions].

作者信息

Tunian Iu S, Sekoian E S, Karagezian K G, Grigorian R A, Manucharian G G, Karagian A T

出版信息

Vopr Kurortol Fizioter Lech Fiz Kult. 1999 Jan-Feb(1):19-23.

Abstract

Effects of Arzni effervescent mineral baths (EMB) on brain tissue metabolism were studied on white rats (normal controls and those with transitory cerebral ischemia). It was found that EMB prevent ischemia-related disorders of phospholipid and adeninnucleotide pools, promote an increase in vasoactive prostaglandins in brain tissue, shifts in catecholamines concentrations in the hemispheres and hypothalamus, inhibit the activity of monoaminoxidase and absorption of 3H-noradrenaline by brains sections. Mechanisms of neuroprotective action of Arzni EMB in cerebral ischemia are considered.

摘要

研究了阿尔兹尼泡腾矿泉浴(EMB)对白色大鼠(正常对照组和短暂性脑缺血大鼠)脑组织代谢的影响。发现EMB可预防与缺血相关的磷脂和腺苷酸池紊乱,促进脑组织中血管活性前列腺素的增加,引起大脑半球和下丘脑中儿茶酚胺浓度的变化,抑制单胺氧化酶的活性以及脑切片对3H-去甲肾上腺素的吸收。文中还探讨了阿尔兹尼EMB在脑缺血中的神经保护作用机制。

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