Chang M C, Wu M S, Wang H H, Wang H P, Lin J T
Department of Internal Medicine, National Taiwan University Hospital, Taipei, R.O.C.
Hepatogastroenterology. 1999 Jan-Feb;46(25):299-302.
BACKGROUND/AIMS: To access the reliability of a newly developed test, the Helicobacter pylori (H. pylori) stool antigen (HpSA) test was used for detection of H. pylori infection.
Stool specimens were collected from 33 consecutive patients (19 males and 14 females, age range: 16-73 years, mean: 49 years) who received upper gastrointestinal endoscopic examination for gastrointestinal symptoms. The H. pylori status was evaluated based on six different tests: culture, histology, biopsy urease test, 13C-urea breath test (13C-UBT), serology, and HpSA test. A commercial kit using an enzyme-linked immunosorbent assay examined HpSA in the stool. H. pylori status was defined as positive when the culture was positive or concordance of three of the other four tests (histology, biopsy urease test, 13C-UBT, and serology) was positive.
Twenty patients were diagnosed as H. pylori-positive. The HpSA test was positive in 19 patients and negative in 14 patients. The sensitivity and specificity were 95.0% and 100%, respectively. The overall accuracy rate was 96.3%.
The HpSA test is a new, simple, non-invasive method for accurate diagnosis of H. pylori infection.
背景/目的：为评估一种新开发检测方法的可靠性，采用幽门螺杆菌（H. pylori）粪便抗原（HpSA）检测来检测幽门螺杆菌感染。
连续收集33例因胃肠道症状接受上消化道内镜检查患者（19例男性，14例女性，年龄范围：16 - 73岁，平均49岁）的粪便标本。基于六种不同检测评估幽门螺杆菌感染状态：培养、组织学检查、活检尿素酶试验、13C - 尿素呼气试验（13C - UBT）、血清学检测和HpSA检测。使用酶联免疫吸附测定的商业试剂盒检测粪便中的HpSA。当培养结果为阳性或其他四项检测（组织学检查、活检尿素酶试验、13C - UBT和血清学检测）中的三项结果一致为阳性时，幽门螺杆菌感染状态定义为阳性。
20例患者被诊断为幽门螺杆菌阳性。HpSA检测中19例患者结果为阳性，14例患者结果为阴性。敏感性和特异性分别为95.0%和100%。总体准确率为96.3%。
HpSA检测是一种用于准确诊断幽门螺杆菌感染的新型、简单、非侵入性方法。
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