Machemer R
Br J Ophthalmol. 1978 Nov;62(11):737-47. doi: 10.1136/bjo.62.11.737.
Massive periretinal proliferation (MPP), a serious complication of retinal detachment, is caused by proliferation and fibrous metaplasia of cells mostly deriving from retinal pigment epithelium and retinal glial cells. Contracting fibrous membranes in the vitreous, and on and also under the retina, cause the intraocular changes of MPP. Early signs such as increased 'tobacco dust', pigmented and unpigmented clumps in the vitreous, and subtle preretinal and even retroretinal membranes are usually overlooked. The late signs such as starfolds, irregular retinal folds, circumferential folds, and funnel-shaped detachments are well known. The pathogenesis of the clinically visible signs is described, and a 4-stage classification of the disease is given.
大量视网膜周增生（MPP）是视网膜脱离的一种严重并发症，主要由大多源自视网膜色素上皮和视网膜神经胶质细胞的细胞增殖和纤维化生引起。玻璃体以及视网膜上和视网膜下的纤维膜收缩，导致MPP的眼内改变。早期体征，如“烟尘”增多、玻璃体中色素性和非色素性团块以及细微的视网膜前甚至视网膜后膜，通常会被忽视。晚期体征，如星状皱襞、不规则视网膜皱襞、环形皱襞和漏斗状脱离，则为人熟知。本文描述了临床可见体征的发病机制，并给出了该病的四阶段分类。
