Gul'kin A V, Voronkov I F
Farmakol Toksikol. 1976 Sep-Oct;39(5):582-6.
In tests staged on cats the effect of apressin and euphylline on the biopotential and electrolytes metabolism was studied. Apressin was found to raise the negative electricity of the biopotential and the potassium level in the vascular tissue, an increase of the dose producing not any further reduction, but rather a higher concentration of calcium in the arterial vessels. Euphyliine causes no changes in the biopotential, but then raises the potassium content in the vascular wall. An accertion of the euphylline dose blocks the egress of calcium from the muscular tissue of the arteries. It is suggested that the relaxing action of the introduced substances maycome about owing to stimulation of the processes infolving binding of calcium in the smooth muscle cells, while changes in the transparietal potential difference are conditioned mainly by counter-gradient transport of potassium.
在对猫进行的实验中，研究了加压素和氨茶碱对生物电位及电解质代谢的影响。发现加压素可提高生物电位的负电荷以及血管组织中的钾水平，剂量增加并不会进一步降低，反而会使动脉血管中的钙浓度升高。氨茶碱不会引起生物电位变化，但会提高血管壁中的钾含量。氨茶碱剂量增加会阻止钙从动脉肌肉组织中流出。有人认为，所引入物质的舒张作用可能是由于刺激了平滑肌细胞中涉及钙结合的过程，而跨壁电位差的变化主要由钾的逆梯度转运所调节。
