The role of the glucose-6-phosphate in the phosphorylase b kinase activation found in perfused rat hearts treated by dinitrophenol.

In order to explain the phosphorylase b kinase activation found in perfused rat hearts treated by dinitrophenol, the glucose-6-phosphate levels and the enzyme activity were determined. Experiments were also done to determine the phosphorylase b kinase inhibition by the ester. The low glucose-6-phosphate levels and the enzyme inhibition found, suggested that the phosphorylase b kinase is activated by a mechanism that involves phosphofructokinase.