Ozyol M B, Voigt K H, Fehm H L, Schmidt K, Herfarth C
Langenbecks Arch Chir. 1976;Suppl:87-90.
This article offers criteria for the surgical treatment of pituitary-dependent Cushing's syndrome. Patients (n = 6) who showed no secondary complications of Cushing's disease underwent an implantation of 90Y and/or 192Ir into the pituitary gland. After implantation the excessive secretion of ACTH was suppressed to normal values and the symptoms of Cushing's syndrome disappeared. Following operation several patients received substitute therapy with other pituitary hormones. Fertility was not always conserved. Total adrenalectomy as alternative therapy was performed in adults with threatening symptoms of the disease (n = 4) and in children (n = 4). The symptoms of Cushing's syndrome disappeared. In two cases the development of a Nelson's tumor was observed. One was treated by implantation of 192Ir into the pituitary gland; the second needs no therapy up to now.
本文提供了垂体依赖性库欣综合征的外科治疗标准。6例无库欣病继发并发症的患者接受了钇-90和/或铱-192垂体植入术。植入后促肾上腺皮质激素（ACTH）的过度分泌被抑制至正常水平，库欣综合征症状消失。术后部分患者接受了其他垂体激素替代治疗。生育功能并非总能保留。对于有严重疾病症状的成人（4例）和儿童（4例），进行了全肾上腺切除术作为替代治疗。库欣综合征症状消失。观察到2例出现尼尔森肿瘤。1例通过垂体植入铱-192进行治疗；另1例至今无需治疗。
