基于中值根先验的迭代重建在心肌血流和氧代谢定量中的应用

Iterative reconstruction based on median root prior in quantification of myocardial blood flow and oxygen metabolism.

作者信息

Katoh C, Ruotsalainen U, Laine H, Alenius S, Iida H, Nuutila P, Knuuti J

机构信息

Turku PET Centre, Finland.

出版信息

J Nucl Med. 1999 May;40(5):862-7.

PMID:10319762

Abstract

UNLABELLED

The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of myocardial blood flow and oxygen metabolism with 15O-labeled tracers and PET. A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered backprojection (FBP) reconstruction method, which is traditionally used for image reconstruction in PET studies.

METHODS

Regional myocardial blood flow (rMBF), oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO2) were quantified from images reconstructed in 27 subjects using both MRP and FBP methods. For each subject, regions of interest (ROIs) were drawn on the lateral, anterior and septal regions on four planes. To test reproducibility, the ROI drawing procedure was repeated. By using two sets of ROIs, variability was evaluated from images reconstructed with the MRP and the FBP methods.

RESULTS

Correlation coefficients of mean values of rMBF, rOEF and rMMRO2 were significantly higher in the images reconstructed with the MRP reconstruction method compared with the images reconstructed with the FBP method (rMBF: MRP r = 0.896 versus FBP r = 0.737, P < 0.001; rOEF: 0.915 versus 0.855, P < 0.001; rMMRO2: 0.954 versus 0.885, P < 0.001). Coefficient of variation for each parameter was significantly lower in MRP images than in FBP images (rMBF: MRP 23.5% +/- 11.3% versus FBP 30.1% +/- 14.7%, P < 0.001; rOEF: 21.0% +/- 11.1% versus 32.1% +/- 19.8%, P < 0.001; rMMRO2: 23.1% +/- 13.2% versus 30.3% +/- 19.1%, P < 0.001).

CONCLUSION

The MRP reconstruction method provides higher reproducibility and lower variability in the quantitative myocardial parameters when compared with the FBP method. This study shows that the new MRP reconstruction method improves accuracy and stability of clinical quantification of myocardial blood flow and oxygen metabolism with 15O and PET.

摘要

未标注

本研究旨在比较两种重建方法在使用(^{15}O)标记示踪剂和正电子发射断层扫描（PET）定量心肌血流和氧代谢方面的可重复性和准确性。将一种基于中位数根先验（MRP）的新型迭代贝叶斯重建方法与传统用于PET研究图像重建的滤波反投影（FBP）重建方法进行比较。

方法

使用MRP和FBP方法从27名受试者重建的图像中定量区域心肌血流（rMBF）、氧摄取分数（rOEF）和心肌氧消耗代谢率（rMMRO2）。对于每个受试者，在四个平面的外侧、前壁和间隔区域绘制感兴趣区（ROI）。为测试可重复性，重复ROI绘制过程。通过使用两组ROI，评估用MRP和FBP方法重建图像的变异性。

结果

与用FBP方法重建的图像相比，用MRP重建方法重建的图像中rMBF、rOEF和rMMRO2平均值的相关系数显著更高（rMBF：MRP r = 0.896，FBP r = 0.737，P < 0.001；rOEF：0.915对0.855，P < 0.001；rMMRO2：0.954对0.885，P < 0.001）。MRP图像中每个参数的变异系数显著低于FBP图像（rMBF：MRP 23.5% ± 11.3%，FBP 30.1% ± 14.7%，P < 0.001；rOEF：21.0% ± 11.1%对32.1% ± 19.8%，P < 0.001；rMMRO2：23.1% ± 13.2%对30.3% ± 19.1%，P < 0.001）。