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[孕妇颅内动静脉畸形]

[Intracranial arteriovenous malformations in pregnant women].

作者信息

Perquin D A, Kloet A, Tans J T, Witte G N, Dörr P J

机构信息

Medisch Centrum Haaglanden, Locatie Westeinde Ziekenhuis, Den Haag.

出版信息

Ned Tijdschr Geneeskd. 1999 Mar 6;143(10):497-500.

Abstract

Three women, aged 27, 32 and 30 years, respectively, suffered from headache, nausea and neurological abnormalities and were found to have an intracranial arteriovenous malformation (AVM). One of them after diagnosis had two pregnancies, both ended by caesarean section with good results. Another woman was 32 weeks pregnant when the AVM manifested itself with a haemorrhage; she recovered well and was delivered by caesarean section. After the AVM proved radiologically to have been obliterated, she delivered after her subsequent pregnancy by the vaginal route with vacuum extraction. The third woman was 15 weeks pregnant when major abnormalities developed. There was a large intracerebral haematoma with break-through to the ventricular system; this patient died. Intracranial haemorrhage during pregnancy is rate. It can result in maternal and foetal morbidity and mortality. It appears that pregnancy does not increase the rate of first cerebral haemorrhage from an AVM. The management of AVM rupture during pregnancy should be based primarily on neurosurgical rather than on obstetric considerations. Close collaboration with a team of neurologists, neurosurgeons, obstetricians and anaesthesiologists is mandatory.

摘要

三名女性,年龄分别为27岁、32岁和30岁,均患有头痛、恶心及神经功能异常,经检查发现患有颅内动静脉畸形(AVM)。其中一名女性确诊后怀孕两次,均通过剖宫产结束妊娠,结果良好。另一名女性在怀孕32周时AVM出现出血;她恢复良好,并通过剖宫产分娩。在影像学检查证明AVM已闭塞后,她在随后的妊娠中通过阴道真空吸引分娩。第三名女性在怀孕15周时出现严重异常。出现大量脑内血肿并破入脑室系统;该患者死亡。妊娠期颅内出血发生率较低。它可导致母婴发病和死亡。看来妊娠不会增加AVM首次脑出血的发生率。妊娠期AVM破裂的处理应主要基于神经外科而非产科考虑。必须与神经科医生、神经外科医生、产科医生和麻醉医生团队密切合作。

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