电针镇痛与伏隔核多巴胺受体之间的关系。
Relationship between electroacupuncture analgesia and dopamine receptors in nucleus accumbens.
作者信息
Wang Y Q, Cao X D, Li K Y, Wu G C
机构信息
Department of Neurobiology, Shanghai Medical University, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Nov;18(6):494-6.
AIM
To study the roles of dopamine (DA) D1 and D2 receptors in nucleus accumbens in electroacupuncture analgesia (EAA) and the potentiation of EAA of rats induced by l-tetrahydropalmatine (l-THP), a dopamine receptor antagonist.
METHODS
SK&F-38393 and quinpirole hydrochloride (Qui), highly selective agonists of D1 and D2 receptors, respectively were injected into nucleus accumbens of rats.
RESULTS
SK&F-38393 (5 and 10 micrograms) attenuated the potentiation of EAA induced by l-THP, 10 micrograms SKF38393 attenuated EAA as well, while Qui (10 and 20 micrograms) had no effect on EAA and the potentiation of EAA induced by l-THP.
CONCLUSION
D1 but not D2 receptor in nucleus accumbens play an important role in EAA and the potentiation of EAA induced by l-THP.
目的
研究伏隔核中多巴胺（DA）D1和D2受体在电针镇痛（EAA）以及多巴胺受体拮抗剂左旋四氢巴马汀（l-THP）诱导的大鼠EAA增强效应中的作用。
方法
分别将D1和D2受体的高选择性激动剂SK&F-38393和盐酸喹吡罗（Qui）注入大鼠伏隔核。
结果
SK&F-38393（5微克和10微克）减弱了l-THP诱导的EAA增强效应，10微克的SKF38393也减弱了EAA，而Qui（10微克和20微克）对EAA以及l-THP诱导的EAA增强效应均无影响。
结论
伏隔核中的D1而非D2受体在EAA以及l-THP诱导的EAA增强效应中起重要作用。
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