核糖体蛋白L8的果蝇同源物。

The Drosophila homologue of ribosomal protein L8.

作者信息

Ruhf M L, Meister M

机构信息

Unité Propre de Recherche 9022, Réponse Immunitaire et Développement chez les Insectes, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

出版信息

Insect Biochem Mol Biol. 1999 Apr;29(4):349-53. doi: 10.1016/s0965-1748(99)00009-0.

DOI:10.1016/s0965-1748(99)00009-0

PMID:10333574

Abstract

We have cloned the gene encoding the Drosophila melanogaster homologue of ribosomal protein L8. It contains two introns: one in the 5' untranslated region and the second in the beginning of the ORF, and encodes a 256-residue protein which is highly conserved when compared with RpL8 proteins of other organisms. The gene is present as a single copy in the Drosophila genome and maps at position 62E6-7 on polytene chromosomes. It is expressed ubiquitously at all stages of development. It is located close to the gene encoding RpL12 and both are candidate targets of the Minute mutation, M(3)LS2, mapped in the region 62E-63A.

摘要

我们已经克隆了编码果蝇核糖体蛋白L8同源物的基因。它含有两个内含子：一个在5'非翻译区，另一个在开放阅读框起始处，编码一个256个氨基酸残基的蛋白质，与其他生物体的RpL8蛋白相比高度保守。该基因在果蝇基因组中以单拷贝形式存在，定位于多线染色体的62E6 - 7位置。它在发育的所有阶段均普遍表达。它位于编码RpL12的基因附近，两者都是定位在62E - 63A区域的微小突变M(3)LS2的候选靶点。