UDP-N-乙酰葡糖胺2-差向异构酶：细胞表面唾液酸化的调节因子。

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation.

作者信息

Keppler O T, Hinderlich S, Langner J, Schwartz-Albiez R, Reutter W, Pawlita M

机构信息

Applied Tumor Virology Program, Tumor Immunology Program, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

出版信息

Science. 1999 May 21;284(5418):1372-6. doi: 10.1126/science.284.5418.1372.

DOI:10.1126/science.284.5418.1372

PMID:10334995

Abstract

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.

摘要

用唾液酸修饰细胞表面分子对其在许多生物学过程中的功能至关重要，这些过程包括细胞黏附和信号转导。尿苷二磷酸-N-乙酰葡糖胺2-表异构酶（UDP-GlcNAc 2-表异构酶）是一种催化唾液酸生物合成途径中早期限速步骤的酶。UDP-GlcNAc 2-表异构酶被发现是人类造血细胞系中细胞表面唾液酸化的主要决定因素，也是特定细胞表面黏附分子功能的关键调节因子。