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人绒毛膜促性腺激素注射前后的血清孕酮水平取决于体外受精-胚胎移植周期中雌二醇对卵巢过度刺激的反应。

Serum progesterone before and after human chorionic gonadotropin injection depends on the estradiol response to ovarian hyperstimulation during in vitro fertilization-embryo transfer cycles.

作者信息

Lindheim S R, Cohen M A, Chang P L, Sauer M V

机构信息

Department of Obstetrics and Gynecology, Columbia University College of Physicians & Surgeons, Columbia-Presbyterian Medical Center, New York, New York, USA.

出版信息

J Assist Reprod Genet. 1999 May;16(5):242-6. doi: 10.1023/a:1020311328182.

DOI:10.1023/a:1020311328182
PMID:10335470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455702/
Abstract

PURPOSE

Our purpose was to assess if periovulatory serum progesterone is reflective of ovarian responsiveness in controlled ovarian hyperstimulation (COH).

METHODS

One-hundred forty-two in vitro fertilization-embryo transfer cycles in women using GnRH-a suppression and human menopausal gonadotropin (hMG) stimulation were evaluated. Responses were studied according to ovarian response to hMG and age. Outcome measures included peak serum estradiol, serum progesterone and estrogen/progesterone ratios on the day of hCG injection, number of harvested oocytes, fertilization rates, and delivered pregnancy rates.

RESULTS

A periovulatory rise in serum progesterone (> 0.9 ng/ml) occurred only among younger women (< 40 years old) with a good response (P < 0.05). Though the number of oocytes was greater in good responders, fertilization and pregnancy rates were similar among all women regardless of age and ovarian response.

CONCLUSIONS

Periovulatory levels of serum progesterone vary according to ovarian response to COH. Elevations in progesterone do not appear to be a manifestation of poor responders. Reduced periovulatory progesterone may reflect inadequate steroidogenesis.

摘要

目的

我们的目的是评估在控制性卵巢过度刺激（COH）中，围排卵期血清孕酮是否反映卵巢反应性。

方法

对142例使用促性腺激素释放激素激动剂（GnRH-a）抑制和人绝经期促性腺激素（hMG）刺激的女性体外受精-胚胎移植周期进行评估。根据卵巢对hMG的反应和年龄研究反应情况。观察指标包括注射hCG当天的血清雌二醇峰值、血清孕酮和雌激素/孕酮比值、采集的卵母细胞数量、受精率和分娩妊娠率。

结果

血清孕酮围排卵期升高（>0.9 ng/ml）仅发生在反应良好的年轻女性（<40岁）中（P<0.05）。尽管反应良好者的卵母细胞数量较多，但所有女性的受精率和妊娠率相似，与年龄和卵巢反应无关。

结论

血清孕酮围排卵期水平因卵巢对COH的反应而异。孕酮升高似乎不是反应不良者的表现。围排卵期孕酮降低可能反映类固醇生成不足。

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本文引用的文献

1
Premature luteinization: could it be an early manifestation of low ovarian reserve?
Fertil Steril. 1998 Mar;69(3):461-5. doi: 10.1016/s0015-0282(97)00561-x.
2
Consequences of premature progesterone elevation on the outcome of in vitro fertilization: insights into a controversy.
Fertil Steril. 1997 Nov;68(5):799-805. doi: 10.1016/s0015-0282(97)00337-3.
3
Premature elevation of plasma progesterone alters pregnancy rates of in vitro fertilization and embryo transfer.
Fertil Steril. 1993 May;59(5):1090-4. doi: 10.1016/s0015-0282(16)55933-0.
4
Premature luteinization in controlled ovarian hyperstimulation has no adverse effect on oocyte and embryo quality.
Fertil Steril. 1993 Oct;60(4):675-9. doi: 10.1016/s0015-0282(16)56221-9.
5
Premature luteinization as detected by elevated serum progesterone is associated with a higher pregnancy rate in donor oocyte in-vitro fertilization.
Hum Reprod. 1993 Sep;8(9):1506-11. doi: 10.1093/oxfordjournals.humrep.a138288.
6
Elevated serum progesterone levels on the day of human chorionic gonadotropin administration in in vitro fertilization cycles do not adversely affect embryo quality.
Fertil Steril. 1994 Mar;61(3):508-13. doi: 10.1016/s0015-0282(16)56584-4.
7
Elevated serum progesterone levels on the day of human chorionic gonadotropin administration do not predict outcome in assisted reproduction cycles.
Fertil Steril. 1994 Nov;62(5):1011-7. doi: 10.1016/s0015-0282(16)57066-6.
8
Increases in progesterone after human chorionic gonadotropin administration may predict cycle outcome in patients undergoing in vitro fertilization-embryo transfer.
Fertil Steril. 1994 Nov;62(5):1066-8.
9
Tripling of serum progesterone (P4) and embryonic morphological features in conception and nonconception cycles, after human in vitro fertilization.
J In Vitro Fert Embryo Transf. 1988 Jun;5(3):161-6. doi: 10.1007/BF01131180.
10
Lower pregnancy rate with premature luteinization during pituitary suppression with leuprolide acetate.
Fertil Steril. 1991 Mar;55(3):563-6.

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