Hisashi K, Komune S, Nakagawa T, Kimitsuki T, Komiyama S
Department of Otorhinolaryngology, Yamaguchi Red Cross Hospital, Japan.
Eur Arch Otorhinolaryngol. 1999;256 Suppl 1:S2-5. doi: 10.1007/pl00014147.
The regulation of K+ and Na+ in the inner ear fluid of the guinea pig was studied after the application of saturated NaCl solution to the round window membrane. K+ and Na+ activities in the scala tympani increased rapidly and then decreased. K+ activity in the scala media increased immediately, but Na+ activity continued to increase during the period of observation. K+ activity in the scala vestibuli continued to increase in the observation period. Na+ activity in the scala vestibuli increased and then decreased. The endocochlear potential decreased immediately to approximately 20% of its initial level. Total activities of K+ and Na+ increased immediately and then decreased in both the scala tympani and scala media. The total activity of K+ and Na+ increased slowly and showed no regulatory decrease in the scala vestibuli. Thus, changing patterns in the total activity of K+ and Na+ were similar for the scala tympani and scala media, but not for the scala media and the scala vestibuli. Different patterns of K+ and Na+ activities among the three scalae indicate that their mechanisms for regulating inner ear fluid differ.
在向豚鼠圆窗膜施加饱和氯化钠溶液后，研究了其内耳液中钾离子（K⁺）和钠离子（Na⁺）的调节情况。鼓阶中的K⁺和Na⁺活性迅速升高，随后降低。中阶中的K⁺活性立即升高，但在观察期内Na⁺活性持续升高。前庭阶中的K⁺活性在观察期内持续升高。前庭阶中的Na⁺活性先升高后降低。内淋巴电位立即降至其初始水平的约20%。鼓阶和中阶中K⁺和Na⁺的总活性立即升高，随后降低。前庭阶中K⁺和Na⁺的总活性缓慢升高，且未出现调节性降低。因此，鼓阶和中阶中K⁺和Na⁺总活性的变化模式相似，但中阶和前庭阶不同。三个阶中K⁺和Na⁺活性的不同模式表明它们调节内耳液的机制不同。
