向豚鼠圆窗膜施加饱和氯化钠溶液后内耳液体在耳蜗中的调节。

Regulation of inner ear fluid in the guinea pig cochlea after the application of saturated NaCl solution to the round window membrane.

作者信息

Hisashi K, Komune S, Nakagawa T, Kimitsuki T, Komiyama S

机构信息

Department of Otorhinolaryngology, Yamaguchi Red Cross Hospital, Japan.

出版信息

Eur Arch Otorhinolaryngol. 1999;256 Suppl 1:S2-5. doi: 10.1007/pl00014147.

DOI:10.1007/pl00014147

PMID:10337516

Abstract

The regulation of K+ and Na+ in the inner ear fluid of the guinea pig was studied after the application of saturated NaCl solution to the round window membrane. K+ and Na+ activities in the scala tympani increased rapidly and then decreased. K+ activity in the scala media increased immediately, but Na+ activity continued to increase during the period of observation. K+ activity in the scala vestibuli continued to increase in the observation period. Na+ activity in the scala vestibuli increased and then decreased. The endocochlear potential decreased immediately to approximately 20% of its initial level. Total activities of K+ and Na+ increased immediately and then decreased in both the scala tympani and scala media. The total activity of K+ and Na+ increased slowly and showed no regulatory decrease in the scala vestibuli. Thus, changing patterns in the total activity of K+ and Na+ were similar for the scala tympani and scala media, but not for the scala media and the scala vestibuli. Different patterns of K+ and Na+ activities among the three scalae indicate that their mechanisms for regulating inner ear fluid differ.

摘要

在向豚鼠圆窗膜施加饱和氯化钠溶液后，研究了其内耳液中钾离子（K⁺）和钠离子（Na⁺）的调节情况。鼓阶中的K⁺和Na⁺活性迅速升高，随后降低。中阶中的K⁺活性立即升高，但在观察期内Na⁺活性持续升高。前庭阶中的K⁺活性在观察期内持续升高。前庭阶中的Na⁺活性先升高后降低。内淋巴电位立即降至其初始水平的约20%。鼓阶和中阶中K⁺和Na⁺的总活性立即升高，随后降低。前庭阶中K⁺和Na⁺的总活性缓慢升高，且未出现调节性降低。因此，鼓阶和中阶中K⁺和Na⁺总活性的变化模式相似，但中阶和前庭阶不同。三个阶中K⁺和Na⁺活性的不同模式表明它们调节内耳液的机制不同。