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[非穿透性深层巩膜切除术治疗慢性开角型青光眼。中期结果]

[Non-penetrating deep sclerectomy in the surgical treatment of chronic open-angle glaucoma. Mid-term results].

作者信息

Massy J, Gruber D, Muraine M, Brasseur G

机构信息

Service d'Ophtalmologie, Hôpital Charles Nicolle, Rouen.

出版信息

J Fr Ophtalmol. 1999 Apr;22(3):292-8.

Abstract

PURPOSE

Non-penetrating deep sclerectomy has been performed in France since the early nineties and appears to be an interesting alternative to Cairn's trabeculectomy. The technical characteristics, the ability to use antimitotic procedures and postoperative YAG laser goniotomy contribute to make deep sclerectomy an attractive surgical method. We evaluated its efficacy and adverse effects in a mid-term retrospective series.

PATIENTS AND METHODS

Fifty patients (all POAG) without usually accepted failure risks for trabeculectomy (trabeculoretraction less than 3 months, intraocular anterior or posterior lens, aphakia, black or Asian subject, failure of previous surgical procedure, patients under 40) underwent this surgical procedure between June 96 and October 97 performed by several skilled surgeons in our unit. This was the first antiglaucoma surgical procedure for all patients. Collagen draining implant was not used. Two pressure criteria (21 mmHg and 16 mmHg) were used to assess success. Success rate and adverse effects were compared with previously published data using the Kaplan-Meier test.

RESULTS

Medium follow-up was 14.24 months. The success rate was 81% (IOP 21 mmHg) and 50% (IOP 16 mmHg) at maximum follow-up of 18 months. There was no statistical difference between treated and untreated groups for target IOP at 21 mmHg (p = 0.12). These results were comparable to those in previous studies and to those obtained with trabeculectomy. The complication rate was low (hyphema 0%, choroidal detachment 2%, hypothalamia 2%, endocular infection 0%).

DISCUSSION

Our success rate and complication rate were comparable with previously published series. Choosing a target IOP of 16 mmHg allowed a better comparison between daily clinical observations and mid-term results, showing a significant difference from the 21 mmHg target. Nevertheless, the success rate was comparable to that obtained with trabeculectomy and the complication rate was lower, supporting the favorable opinion concerning deep sclerectomy.

CONCLUSION

Non-penetrating deep sclerectomy appears to be as efficient as Cairn's trabeculectomy for surgical treatment of glaucoma and allows a lower complication rate. Long-term results, visual field and papilla remain to be evaluated. Furthermore, results with a pressure goal of 16 mmHg are interesting to evaluate because they reflect the real clinical situation better than the target 21 mmHg IOP. This technique should be evaluated in other forms of glaucoma.

摘要

目的

自九十年代初起,非穿透性深层巩膜切除术就在法国开展,它似乎是对 Cairn 小梁切除术的一种有吸引力的替代方法。其技术特点、使用抗有丝分裂程序的能力以及术后 YAG 激光周边虹膜切开术,使得深层巩膜切除术成为一种有吸引力的手术方法。我们在一个中期回顾性系列研究中评估了其疗效和不良反应。

患者与方法

五十名患者(均为原发性开角型青光眼),没有通常被认为的小梁切除术失败风险(小梁退缩少于 3 个月、眼内晶状体前后位、无晶状体、黑人或亚洲人种、既往手术失败、40 岁以下患者),于 1996 年 6 月至 1997 年 10 月间在我们科室由几位经验丰富的外科医生进行了该手术。这是所有患者的首次抗青光眼手术。未使用胶原引流植入物。采用两个眼压标准(21 mmHg 和 16 mmHg)来评估手术成功与否。使用 Kaplan-Meier 检验将成功率和不良反应与先前发表的数据进行比较。

结果

平均随访时间为 14.24 个月。在最长 18 个月的随访中,眼压≤21 mmHg 时的成功率为 81%,眼压≤16 mmHg 时的成功率为 50%。在眼压目标为 21 mmHg 时,治疗组和未治疗组之间无统计学差异(p = 0.12)。这些结果与先前研究的结果以及小梁切除术的结果相当。并发症发生率较低(前房积血 0%,脉络膜脱离 2%,低眼压 2%,眼内感染 0%)。

讨论

我们的成功率和并发症发生率与先前发表的系列研究相当。选择 16 mmHg 的眼压目标能使日常临床观察与中期结果之间有更好的比较,显示出与 21 mmHg 目标有显著差异。然而,成功率与小梁切除术相当,且并发症发生率更低,这支持了对深层巩膜切除术的有利看法。

结论

非穿透性深层巩膜切除术在青光眼手术治疗中似乎与 Cairn 小梁切除术一样有效,且并发症发生率更低。长期结果、视野及视乳头情况仍有待评估。此外,以 16 mmHg 为眼压目标的结果值得评估,因为它们比 21 mmHg 的眼压目标能更好地反映实际临床情况。该技术应在其他类型的青光眼中进行评估。

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