骨肉瘤肺转移的外科治疗。附206例手术病例

[Surgical treatment of pulmonary metastases of osteosarcoma. Apropos of 206 operated cases].

作者信息

Briccoli A, Ferrari S, Picci P, Mercuri M, Bacci G, Guernelli N

机构信息

Département de Chirurgie, Université de Modène, Italie.

出版信息

Ann Chir. 1999;53(3):207-14.

PMID:10339862

Abstract

Two hundred and six patients were operated for lung metastases from osteosarcoma over a period of 7 years. The operative mortality was 0.3%. The actuarial survival for the overall population was 78% at one year. 50% at two years, 40% at three years and 34% at five years. The most significant prognostic factors (p < 0.01) were the number of metastases, the duration of the free interval and the degree of differentiation. Sex, age, site and type of resection of osteosarcoma or the metastases did not have any influence on prognosis. Surgical resection of lung metastases currently constitutes an essential part of the multidisciplinary management of osteosarcoma.

摘要

在7年的时间里，206例骨肉瘤肺转移患者接受了手术治疗。手术死亡率为0.3%。总体人群的精算生存率在1年时为78%，2年时为50%，3年时为40%，5年时为34%。最显著的预后因素（p<0.01）是转移灶数量、无瘤间期持续时间和分化程度。骨肉瘤或转移灶的性别、年龄、部位及切除类型对预后均无影响。目前，肺转移灶的手术切除是骨肉瘤多学科治疗的重要组成部分。