微晶纤维素颗粒对片剂抗张强度的形态学影响。

Morphological effect of microcrystalline cellulose particles on tablet tensile strength.

作者信息

Obae K, Iijima H, Imada K

机构信息

Functional Additives Technology Department One, Asahi Chemical Industry Co., Ltd., 6-2700 Asahi-cho, Nobeoka, Miyazaki 882-0847, Japan.

出版信息

Int J Pharm. 1999 May 25;182(2):155-64. doi: 10.1016/s0378-5173(99)00057-5.

DOI:10.1016/s0378-5173(99)00057-5

PMID:10341305

Abstract

An attempt was made (1) to fractionate microcrystalline cellulose (MCC) particles of Avicel PH-101 (PH grade) and Ceolus KG-801 (KG grade) into four sieve fractions by using an air-jet sieve and (2) to disclose effects of morphology of the particle on tablet tensile strength, T. The morphology of MCC particles is one of the most important factors affecting T. T increased with an increase in the ratio of L/D for particles (L, length; D, width). KG grade consists of a larger number of rod-shaped particles than PH grade, giving significantly higher compressibility than PH grade.

摘要

尝试进行了以下操作

(1) 使用气流筛分仪将微晶纤维素（MCC）的埃维安 PH - 101（PH 级）和赛洛素 KG - 801（KG 级）颗粒分选为四个筛分级分；(2) 揭示颗粒形态对片剂抗张强度 T 的影响。MCC 颗粒的形态是影响 T 的最重要因素之一。T 随颗粒的长径比（L，长度；D，宽度）增加而增加。KG 级颗粒比 PH 级颗粒包含更多的棒状颗粒，其压缩性明显高于 PH 级。