Yang J, Furie B C, Furie B
Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Thromb Haemost. 1999 Jan;81(1):1-7.
Cell-cell interactions mediating leukocyte trafficking, thrombogenesis and inflammation are crucial for the host defense mechanism. The selectin family of integral membrane proteins includes E-selectin, L-selectin and P-selectin. Selectins mediate tethering and rolling of leukocytes to the vessel wall at the site of inflammation. The counter-receptor for P-selectin and possibly the other selectins is P-selectin glycoprotein ligand-1 (PSGL-1). This review focuses on the properties and biology of PSGL- 1.
介导白细胞运输、血栓形成和炎症的细胞间相互作用对于宿主防御机制至关重要。整合膜蛋白的选择素家族包括E-选择素、L-选择素和P-选择素。选择素介导白细胞在炎症部位与血管壁的栓系和滚动。P-选择素以及可能其他选择素的反受体是P-选择素糖蛋白配体-1（PSGL-1）。本综述聚焦于PSGL-1的特性和生物学。
